Flavivirus Inhibitor
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Dianemycin (Standard)
0 ImagesCat. No.: HY-100528ARCAS No.: 35865-33-9Synonyms: Nanchangmycin free acid (Standard)4-Methoxycinnamic acid (Standard) is the analytical standard of 4-Methoxycinnamic acid. This product is intended for research and analytical applications. 4-Methoxycinnamic acid is detected as natural phenylpropanoid in A. preissii.
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NSC-323241
0 ImagesCat. No.: HY-176433CAS No.: 79514-43-5NSC-323241 is a potent STT3A-mediated mega protein complex assembly inhibitor. NSC-323241 disrupts he endoplasmic reticulum (ER) mega complex nucleated by STT3A during dengue virus (DENV) and Zika virus (ZIKV) infection. NSC-323241 targets the binding of STT3A subcomplex with viral nonstructural proteins (e.g., NS2B, NS3) and host translocon proteins, disrupting the formation of viral replication microenvironment. NSC-323241 is promising for research of flavivirus infection, such as dengue fever and Zika virus.
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Antiviral agent 81
0 ImagesCat. No.: HY-182761Antiviral agent 81 is an orally bioavailable N-acylated remdesivir derivative and RdRp inhibitor with 45.3% oral bioavailability (based on active metabolite GS-441524 exposure), plasma half-life >8 h, and reduced CYP3A4 inhibition. Antiviral agent 81 exhibits activity against Coronaviridae, Flaviviridae, and Pneumoviridae, and shows no activity against Orthomyxoviridae, Herpesviridae, and Alphaviridae. Antiviral agent 81 can be used for the research of viral infections.
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Mycophenolic acid sodium (Standard)
0 ImagesSynonyms: Mycophenolate sodium (Standard)Mycophenolic acid (sodium) (Standard) is the analytical standard of Mycophenolic acid (sodium). This product is intended for research and analytical applications. Mycophenolic acid sodium is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 μM. Mycophenolic acid sodium demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid sodium is an immunosuppressive agent. Antiangiogenic and antitumor effects.
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TYT-1
0 ImagesCat. No.: HY-122196CAS No.: 64803-10-7TYT-1 is a sulfonamide-thiourea compound that has inhibitory activity against West Nile virus replication with a 50% effective concentration of 0.7 microM, blocking a post-entry, pre-assembly step of viral replication.
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PS1097
0 ImagesCat. No.: HY-186075CAS No.: 1822320-58-0PS1097 is a broad-spectrum antiviral inhibitor with a BVDV RdRp IC50 of 0.64 μM. PS1097 selectively reduces RTN3 protein levels, causes partial RTN3 mRNA reduction, and leaves other endoplasmic reticulum-resident proteins unaffected. PS1097 inhibits replication of Zika virus and multiple viruses that use the endoplasmic reticulum as a replication hub. PS1097 inhibits BVDV RdRp enzymatic activity and exerts activity against Bovine Viral Diarrhea Virus. PS1097 can be used for the research of zika virus infection, usutu virus infection, west nile virus infection, COVID-19, coxsackie b virus 5 infection, chikungunya virus infection, vaccinia virus infection.
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Anti-Venezuelan equine encephalitis virus E2 protein Antibody (VEEV-57)
0 ImagesCat. No.: HY-P991766Anti-Venezuelan equine encephalitis virus E2 protein Antibody (VEEV-57) reacts with the E2 protein of the Venezuelan equine encephalitis virus (VEEV). Anti-Venezuelan equine encephalitis virus E2 protein Antibody (VEEV-57) inhibits VEEV attachment to Vero cells, viral egress, viral fusion, and LDLRAD3-D1-Fc binding. Recommend Isotype Controls: Mouse IgG2c kappa, Isotype Control (HY-P99981).
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DB772 free base
0 ImagesCat. No.: HY-114621BCAS No.: 433735-90-1DB772 free base is a bovine viral diarrhoea virus (BVDV) inhibitor. DB772 free base also has anti-prion activity.
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Cephaeline (Standard)
0 ImagesSynonyms: (-)-Cephaeline (Standard); NSC 32944 free base (Standard)Cephaeline ((-)-Cephaeline), a desmethyl analog of Emetine, is a phenolic alkaloid in Indian Ipecac roots isolated from the Cephaelis ipecacuanha. Cephaeline exhibits potent inhibition of both Zika virus (ZIKV) and Ebola virus (EBOV) infections. Cephaeline is an inductor of histone H3 acetylation and an inhibitor of mucoepidermoid carcinoma cancer stem cells (MEC), which promotes ferroptosis by inhibiting NRF2 to exert anti-lung cancer efficacy.
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Quinine dihydrochloride
0 ImagesQuinine dihydrochloride is an orally active alkaloid extracted from cinchona bark, possessing various biological activities including antimalarial, antidengue virus (DENV), and anticancer properties. Quinine dihydrochloride is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM.
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HLB-0532247
0 ImagesCat. No.: HY-183873CAS No.: 2850362-12-6HLB-0532247 is a cell-permeable phosphoramidate prodrug of 3'-deoxy-3',4'-didehydrocytidine (ddhC). HLB-0532247 increases the intracellular level of the endogenous antiviral nucleotide ddhCTP (HY-128788). HLB-0532247 reduces the titers of Zika virus and West Nile virus in cell cultures. HLB-0532247 can be used in studies related to Zika virus infection, West Nile virus infection, and coronavirus infection.
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NS2B/NS3-IN-9
0 ImagesCat. No.: HY-179013CAS No.: 812683-94-6NS2B/NS3-IN-9 (Compound 73) is a broad-spectrum, non-competitive anti-Orthoflavivirus lipopeptide inhibitor targeting the NS2B-NS3 protease. NS2B/NS3-IN-9 exhibits IC50 values for Dengue virus DENV2 NS2B-NS3, West Nile virus WNV NS2B-NS3, and Zika virus ZIKV NS2B-NS3 of 2.4, 7.2, and 1.9 μM, respectively. NS2B/NS3-IN-9 also exhibits antiviral activity at the cellular level against DENV2, WNV, and ZIKV, with EC50 values of 4.1, 4.9, and 5.0 μM, respectively. NS2B/NS3-IN-9 has no significant toxicity to cells. NS2B/NS3-IN-9 can be used for the study of anti-Orthoflavivirus.
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SGC-NSP2hel-1
0 ImagesCat. No.: HY-176268Synonyms: RA-0188293; RA-NSP2-1SGC-NSP2hel-1 (RA-0188293), a chemical probe, is a potent, specific and orally active nsP2 inhibitor. SGC-NSP2hel-1 has broad spectrum activity against multiple alphaviruses of the nsP2 helicase with a CC50 > 250 μM. SGC-NSP2hel-1 (RA-0188293) shows selectivity index > 4000 against human RNA helicases. SGC-NSP2hel-1 reduces virus replication and limited virus-induced pathology by forming a stable complex with nsP2 and ATP in a preclinical small animal model of CHIKV disease.
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Galidesivir dihydrochloride
0 ImagesCat. No.: HY-18649BCAS No.: 1373208-51-5Synonyms: BCX4430 dihydrochloride; Immucillin-A dihydrochlorideGalidesivir (BCX4430; Immucillin-A) dihydrochloride is a broad-spectrum RNA virus inhibitor that can inhibit Ebola and yellow fever virus (Flavivirus) infections. Galidesivir has potent antiviral activity against tick-borne encephalitis virus (TBEV) and also inhibits the proliferation of many other medically important flaviviruses.
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NS3-IN-2
0 ImagesCat. No.: HY-189635NS3-IN-2 is a dual-target inhibitor targeting both NS2B‑NS3pro and NS3hel of West Nile virus (WNV). NS3-IN-2 inhibits the enzymatic activity of NS2B‑NS3pro toward polypeptide substrates in a non-competitive manner; for NS3hel, the compound exhibits a non-competitive inhibition mode with respect to ATP and competitive inhibition with respect to the dsDNA substrate. In biochemical assays, NS3-IN-2 has an IC50 = 4.4 μM against NS2B‑NS3pro and an IC50 = 24.0 μM against NS3hel helicase activity. NS3-IN-2 reduces WNV viral replication and exhibits cytotoxicity in hepatoma cells. NS3-IN-2 can be used for research on West Nile virus infection.
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Palonosetron hydrochloride (Standard)
0 ImagesPalonosetron hydrochloride (Standard) is the analytical standard of Palonosetron hydrochloride (HY-A0021). This product is intended for research and analytical applications. Palonosetron hydrochloride is a 5-HT3 antagonist primarily used to prevent acute, delayed, and overall chemotherapy-induced nausea and vomiting. In addition, Palonosetron hydrochloride exhibits moderate anti-flavivirus activity and potent anti-Zika virus activity in mammalian cells. Palonosetron hydrochloride also possesses antidepressant activity.
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CN-716 dihydrochloride
0 ImagesCat. No.: HY-156052CAS No.: 2077164-48-6CN-716 dihydrochloride is a reversible covalent flavivirus NS2B·NS3 protease inhibitor with antiviral activity. CN-716 dihydrochloride effectively inhibits the replication of dengue virus (DENV2), West Nile virus (WNV) and Zika virus (ZIKV). The IC50 values of CN-716 dihydrochloride against the proteases of the above three viruses are 0.066 μM, 0.11 μM and 0.25 μM, respectively, while the Ki values against the same proteases are 0.051 μM, 0.082 μM and 0.04 μM, respectively. CN-716 dihydrochloride can be used to study the infection mechanisms of dengue fever, West Nile fever and Zika virus infection.
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ML-SA1 (Standard)
0 ImagesCat. No.: HY-108462RCAS No.: 332382-54-4ML-SA1 (Standard) is the analytical standard of ML-SA1 (HY-108462). This product is intended for research and analytical applications. ML-SA1, as a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 value of ML-SA1 against DENV2 RNA and ZIKV RNA is 8.3 μM and 52.99 μM, respectively. ML-SA1 induces autophagy. ML-SA1 can be used for the research of broad-spectrum antiviral.
