iGluR
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iGluR Produits associés (456)
Produits associés (456)
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N,N'-Bis(2-aminoethyl)-1,4-butanediamine
0 ImagesCat. No.: HY-184804CAS No.: 35513-90-7N,N'-Bis (2-aminoethyl)-1,4-butanediamine is a GluR6 (Q) kainate subtype glutamate receptor channel blocker, with a Kd (0) of 41.1 μM for the GluR6 (Q) receptor.
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GYKI 52466 dihydrochloride (Standard)
0 ImagesGYKI 52466 (dihydrochloride) (Standard) is the analytical standard of GYKI 52466 (dihydrochloride). This product is intended for research and analytical applications. GYKI 52466 dihydrochloride is an orally active, highly selective and noncompetitive AMPA/kainate receptor antagonist with the IC50 values of 7.5 and 11μM, respectively. GYKI 52466 dihydrochloride has good blood brain barrier permeability and anticonvulsant effect. GYKI 52466 dihydrochloride can be used in Parkinson's disease research.
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Caroverine hydrochloride (Standard)
0 ImagesCat. No.: HY-106467BRCAS No.: 55750-05-5Caroverine (hydrochloride) (Standard) is the analytical standard of Caroverine (hydrochloride). This product is intended for research and analytical applications. Caroverine hydrochloride is a potent, competitive and reversible antagonist of NMDA and AMPA glutamate receptor. Caroverine hydrochloride is also an antioxidant and calcium-blocking agent that exhibits vasorelaxant action. Caroverine hydrochloride can be used for the research of inner ear tinnitus.
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Sunifiram (Standard)
0 ImagesSynonyms: DM-235 (Standard)Sunifiram (Standard) is the analytical standard of Sunifiram. This product is intended for research and analytical applications. Sunifiram (DM-235) is an ampakine-like compound and an agonist of AMPA receptor with oral activity. Sunifiram can increase the release of acetylcholine in the rat cerebral cortex and exhibits potent cognitive enhancement effects with better nootropic activity compared to piracetam (HY-B0585). Sunifiram is promising for research in neurodegenerative diseases such as mild cognitive impairment (MCI) and Alzheimer's disease (AD).
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Co 101244 hydrochloride (Standard)
0 ImagesCat. No.: HY-107706RCAS No.: 193356-17-1Synonyms: PD 174494 hydrochloride (Standard)Co 101244 hydrochloride (Standard) is the analytical standard of Co 101244 (hydrochloride) (HY-107706). This product is intended for research and analytical applications. Co 101244 (PD 174494) hydrochloride is a NR2B-containing NMDA receptor antagonist.
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UBP310 (Standard)
0 ImagesCat. No.: HY-107602RCAS No.: 902464-46-4
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5,7-Dichlorokynurenic acid (Standard)
0 ImagesSynonyms: 5,7-DCKA (Standard)5,7-Dichlorokynurenic acid (Standard) is the analytical standard of 5,7-Dichlorokynurenic acid (HY-100834). This product is intended for research and analytical applications. 5,7-Dichlorokynurenic acid (5,7-DCKA) is a selective and competitive antagonist of the glycine site on NMDA receptor with a KB of 65 nM. 5,7-Dichlorokynurenic acid reduces NMDA-induced neuron injury. 5,7-Dichlorokynurenic acid increases social interaction time, increases open arm exploration time, disinhibits suppressed conflict responding in rodent models. 5,7-Dichlorokynurenic acid exhibits anxiolytic-like activity in rodent models and supports exploration of glycine’s role in NMDA receptor-mediated synaptic transmission.
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Tianeptine sodium salt (Standard)
0 ImagesTianeptine sodium salt (Standard) is the analytical standard of Tianeptine sodium salt (HY-90003A). This product is intended for research and analytical applications. Tianeptine sodium salt is an atypical antidepressant. Tianeptine sodium salt is a moderate-intensity agonist of the μ-opioid receptor (MOR), and to a lesser extent, is an agonist of the δ-opioid receptor (DOR). Tianeptine sodium salt is a glutamate modulator that can enhance AMPA receptor and antagonize NMDA receptor. Tianeptine sodium salt increases sensitivity of the α1 adrenergic receptor, which only manifests in chronic treatment. Tianeptine sodium salt exerts neuroprotective effects under stress/inflammation-induced conditions, exhibiting anti-inflammatory and antioxidant properties. Tianeptine sodium salt inhibits MMP-9 by suppressing the PI3K/Akt-mediated NF-κB pathway. Tianeptine sodium salt can be used to alleviate symptoms of depression and anxiety, but does not cause sedative effects.
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IDRA 21 (Standard)
0 ImagesIDRA 21 (Standard) is the analytical standard of IDRA 21 (HY-101528). This product is intended for research and analytical applications. IDRA 21 is a positive and orally active modulator of the AMPA receptor. IDRA 21 facilitates excitatory neurotransmission via GluR1/2 receptors. IDRA 21 has the potential for the research of cognitive/memory disorders, including those associated with aging.
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Dimiracetam (Standard)
0 ImagesCat. No.: HY-106856RCAS No.: 126100-97-8Synonyms: NT-11624 (Standard)Dimiracetam (Standard) (NT-11624 (Standard)) is the analytical standard of Dimiracetam (HY-106856). This product is intended for research and analytical applications. Dimiracetam is an orally active compound, with anti-neuropathic activity. Dimiracetam inhibits hypersensitivity and neurological alterations, and inhibits Sorafenib (HY-10201)-induced neuropathy in cold stimulation rat models.
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Budipine hydrochloride
0 ImagesCat. No.: HY-W001601ACAS No.: 63661-61-0Budipine hydrochloride is an anti-parkinson agent. Budipine hydrochloride also is a substrate of P-glycoprotein (P-gp), is mediated the uptake into the brain by P-gp. Budipine hydrochloride also is N-methyl-d-aspartate (NMDA) antagonist, and has indirect dopaminergic effects through an improved dopamine release, the inhibition of monoamine oxidase type B (MAO-B). Budipine hydrochloride can be used for the research of CNS disorders include Parkinson disease.
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Aptiganel hydrochloride (Standard)
0 ImagesCat. No.: HY-110097RCAS No.: 137160-11-3Synonyms: CNS 1102 (Standard)Aptiganel (hydrochloride) (Standard) is the analytical standard of Aptiganel (hydrochloride). This product is intended for research and analytical applications. Aptiganel hydrochloride (Cerestat) is a non-competitive NMDA receptor antagonist with neuroprotective effect.
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(R)-(+)-HA-966 (Standard)
0 ImagesSynonyms: (+)-HA-966 (Standard)(R)-(+)-HA-966 (Standard) is the analytical standard of (R)-(+)-HA-966 (HY-100822). This product is intended for research and analytical applications. (R)-(+)-HA-966 ((+)-HA-966) is a partial agonist/antagonist of glycine site of the N-methyl-D-aspartate (NMDA) receptor complex. (R)-(+)-HA-966 selectively blocks the activation of the mesolimbic dopamine system by amphetamine. (R)-(+)-HA-966 can cross the blood-brain barrier and has the potential for neuropathic and acute pain.
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Etoxadrol
0 ImagesCat. No.: HY-107040CAS No.: 28189-85-7Synonyms: NSC 288020; CL-1848CEtoxadrol (CL-1848C) is a potent, high-affinity N-methyl-D-aspartic acid (NMDA) antagonist. Etoxadrol is used in the anaesthetic and anaesthesia research community to suppress or relieve pain.
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LY450108 (Standard)
0 ImagesCat. No.: HY-10935RCAS No.: 376594-67-1LY450108 (Standard) is the analytical standard of LY450108 (HY-10935). This product is intended for research and analytical applications. LY450108 is a potent AMPA receptor potentiator. LY450108 has the potential for depression and ParKinson's disease research.
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HA-966 hydrochloride
0 ImagesCat. No.: HY-W424730CAS No.: 42585-88-6HA-966 hydrochloride is a glycine site antagonist of the NMDA receptor, exhibiting non-competitive antagonism on NMDA responses. HA-966 hydrochloride effectively blocks the enhancement of NMDA responses by glycine in a competitive manner. HA-966 hydrochloride plays a significant role in mediating the antagonist action at the glycine modulatory site of the NMDA receptor.
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GYKI 53655 hydrochloride (Standard)
0 ImagesCat. No.: HY-103228RCAS No.: 143692-48-2Synonyms: LY300168 hydrochloride (Standard)GYKI 53655 hydrochloride (Standard) is the analytical standard of GYKI 53655 hydrochloride (HY-103228). This product is intended for research and analytical applications. GYKI 53655 (LY300168) hydrochloride is an α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) antagonist.
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Toladryl
0 ImagesCat. No.: HY-138110CAS No.: 19804-27-4Synonyms: 4-MethyldiphenhydramineToladryl is a derivative of Diphenhydramine (HY-B0303), capable of penetrating the blood-brain barrier and possessing oral activity, as well as antihistamine and anticholinergic activities. The anticholinergic activity of Toladryl is approximately one-tenth that of Diphenhydramine (HY-B0303), and its protective effect against lethal doses of histamine in guinea pigs is 2 to 4 times that of Diphenhydramine (HY-B0303). The side effects of Toladryl are fewer and milder than those of Diphenhydramine (HY-B0303), but at higher doses, it may cause central nervous system symptoms such as insomnia, agitation, and disorientation. Toladryl can be used for research in allergic diseases.
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CFM-2 (Standard)
0 ImagesCat. No.: HY-12503RCAS No.: 178616-26-7CFM-2 (Standard) is the analytical standard of CFM-2. This product is intended for research and analytical applications. CFM-2 is a potent and selective non-competitive AMPAR antagonist. CFM-2 possesses anticonvulsant activity in various models of seizures.
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D-AP7
0 ImagesCat. No.: HY-107719CAS No.: 81338-23-0D-AP7 is a specific NMDA receptor antagonist with inhibitory activity against epileptiform activity. D-AP7 attenuated neuronal activation in spot activity by reducing the duration and number of exogenously induced bursts. D-AP7 also increased the amplitude of secondary action potentials, which may restore neuronal activity in some epileptiform bursts. D-AP7 showed anxiogenic effects and impaired memory consolidation in passive avoidance learning.
