PI5P4K Inhibitor

NCT-504 is a selective allosteric inhibitor of PIP4Kγ, with an IC₅₀ of 15.8 μM. NCT-504 is potential for the research of Huntington's disease.

BAY-091, a chemical probe, is a potent and highly selective inhibitor of the kinase PIP4K2A.

PIP4K-IN-a131 is PIP4K lipid kinases inhibitor, with IC₅₀s of 1.9 μM and 0.6 μM for purified PIP4K2A and PIP4Ks, respectively. PIP4K-IN-a131 exhibits cancer-selective lethality via dual blockade of the lipid kinase PIP4Ks and mitotic pathways.

CC260 is a selective PI5P4Kα and PI5P4Kβ inhibitor with K_is of 40 nM and 30 nM, respectively. CC260 does not inhibit or weakly inhibits other protein kinases, such as Plk1 and RSK2. CC260 can be used for cell energy metabolism, diabetes and cancer research.

NIH-12848 is a putative phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor with an IC₅₀ of 1 μM.

066ATZ is a PIP4K2A/2B inhibitor with human PIP4K2A K_i 100 nM and PIP4K2B K_i 800 nM. 066ATZ binds to ATP-binding sites of PIP4K2A and PIP4K2B to block lipid kinase activity. 066ATZ can be used for the research of non-small cell lung cancer.

BAY-297 is a PIP4K2A inhibitor. BAY-297 binds to PIP4K2A in intact cells and cell lysates. BAY-297 serves as a chemical probe for investigating the PIP4K2A signaling pathway and its roles in physiological conditions such as cancer.

PI5P4Kγ-IN-1 is an ATP-competitive, highly selective chemical probe for PI5P4Kγ, with a K_d of 19 nM and an IC₅₀ of 67 nM. PI5P4Kγ-IN-1 effectively inhibits PI5P4Kγ function and activates the mTORC1 signaling pathway in cells. PI5P4Kγ-IN-1 can be used in studies related to diseases such as breast cancer.

PI5P4Kα-IN-1 (Compound 13) is a PI5P4Kinhibitor (IC₅₀: 2 and 9.4 μM for PI5P4Kα and PI5P4Kβ). PI5P4Kα-IN-1 can be used for research of cancer, metabolic and immunological disorders.

ARUK2007145 is potent, cell-active dual inhibitor of the PI5P4Kα and PI5P4Kγ isoforms (pIC₅₀: 7.3 and 8.1, respectively).

PI5P4Ks-IN-2 is a inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ). PI5P4Ks-IN-2 targets to PI5P4K isoforms with pIC₅₀ values of <4.3 (PI5P4Kα), <4.6 (PI5P4Kβ), 6.2 (PI5P4Kγ), 0.32 (PI5P4Kγ+), respectively.

ARUK2001607 is a selective phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor with a K_d of 7.1 nM. ARUK2001607 shows high selectivity over other >150 kinases.

CVM-05-002 is a PI5P4K inhibitor, with IC₅₀ values of 0.27 μM and 1.7 μM for PI5P4Kα and PI5P4Kβ, respectively.

PI5P4K-β-IN-1 (compound vs1) is a potent inhibitor of PI5P4K-β (IC₅₀: 0.80 μM).

PI5P4Ks-IN-3 (compound 30) is a covalent inhibitor of PI5P4K with IC₅₀s of 1.34 μM (PI5P4Kα)，and 9.9 μM (PI5P4Kβ)，respectively. PI5P4Ks-IN-3 shows weak cellular activity.

PI5P4K-β-IN-2 (compound d5) is a PI5P4K-β inhibitor (IC₅₀ = 0.35 μM) with antitumor activity.