1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. Tibenelast sodium

Tibenelast sodium (Synonyms: LY 186655)

Cat. No.: HY-101705
Handling Instructions

Tibenelast sodium is a phosphodiesterase inhibitor.

For research use only. We do not sell to patients.

Tibenelast sodium Chemical Structure

Tibenelast sodium Chemical Structure

CAS No. : 105102-18-9

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Tibenelast sodium is a phosphodiesterase inhibitor.

IC50 & Target

phosphodiesterase[1]

In Vitro

The effect of the phosphodiesterase inhibitor Tibenelast, and placebo on isoproterenol-induced changes in heart rate, cAMP and norepinephrine levels in normal male volunteers is studied. Tibenelast increases the heart rate response to isoproterenol infusion, whereas norepinephrine and cAMP levels are not different in any treatment[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Tibenelast is a potent orally active compound against anaphylactic shock induced by high dose antigen aerosol. When a lower aerosol challenge (0.05 mg/mL) is employed, bronchoconstriction is observed with a concomitant increase in lung resistance (RL) and a fall in dynamic compliance (Cdyn). Tibenelast at 25 mg/kg p.o. prevents these changes. Tibenelast is 10 times more potent than Aminophylline by i.v. administration; normalization of pulmonary function is achieved at 1 mg/kg i.v. Tibenelast is synergistic with epinephrine. The oral dose response curve of Tibenelast is enhanced with the co-administration of epinephrine. Tibenelast may be of significant value in the treatment of asthma and other respiratory diseases[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

288.29

Formula

C₁₃H₁₃NaO₄S

CAS No.

105102-18-9

SMILES

O=C(C1=CC2=CC(OCC)=C(OCC)C=C2S1)[O-].[Na+]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

TibenelastLY 186655LY186655LY-186655Phosphodiesterase (PDE)Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Tibenelast sodium
Cat. No.:
HY-101705
Quantity:
MCE Japan Authorized Agent: