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Zoxazolamine 

Cat. No.: HY-B1307
Handling Instructions

Zoxazolamine is widely used for a pharmacologic test that serves as a convenient indicator of changes in cytochrome P-450 activity in rodents.

For research use only. We do not sell to patients.

Zoxazolamine Chemical Structure

Zoxazolamine Chemical Structure

CAS No. : 61-80-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
50 mg USD 50 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Zoxazolamine is widely used for a pharmacologic test that serves as a convenient indicator of changes in cytochrome P-450 activity in rodents.

In Vivo

Zoxazolamine is widely used for a pharmacologic test that serves as a convenient indicator of changes in cytochrome P-450 activity in rodents. The time-averaged serum clearance determined from tested concentrations data is 7.22±1.01 mL/min/kg for Zoxazolamine. Infusion of Zoxazolamine to righting reflex (LRR) at three different rates shows increasing Zoxazolamine concentration in serum and brain at the onset of the effect with increasing infusion rates. When the Zoxazolamine infusion is continued for 5 min beyond the onset of LRR, the concentrations of Zoxazolamine in the cerebrospinal fluid (CSF) at the offset of LRR are essentially identical to the onset concentrations[1].

Solvent & Solubility
In Vitro: 

DMSO : 300 mg/mL (1779.57 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.9319 mL 29.6595 mL 59.3190 mL
5 mM 1.1864 mL 5.9319 mL 11.8638 mL
10 mM 0.5932 mL 2.9660 mL 5.9319 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[1]

Inbred male Lewis rats are used in this study. The animals are allowed 7 to 12 days to adjust to the local animal facilities and to recover possible stress incurred during transport. To compare drug concentrations in serum at the onset and offset of loss of the righting reflex, Zoxazolamine is infused into the femoral vein at a rate of 0.51 mg/min for 5 min beyond the onset of loss of the righting reflex. The infusion solution consists of 10 mg Zoxazolamine in 1 mL normal saline. Then, blood samples from the jugular vein are obtained from four rates at the onset and offset of loss of the righting reflex, using a procedure that yields mainstream blood[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

168.58

Formula

C₇H₅ClN₂O

CAS No.

61-80-3

SMILES

NC1=NC2=CC(Cl)=CC=C2O1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Zoxazolamine
Cat. No.:
HY-B1307
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Zoxazolamine

Cat. No.: HY-B1307