country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-117118

Copy Link Print Information

AC-90179 free base

AC-90179 is a selective 5-HT2A receptor inverse agonist (K_i = 2.1 nM) and 5-HT2C antagonist, a potential antipsychotic compound.

For research use only. We do not sell to patients.

CAS No.: 359878-17-4
Formula: C₂₃H₃₀N₂O₂
Molecular Weight:366.51

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

AC-90179 free base Chemical Structure

CAS No.: 359878-17-4

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

AC-90179 is a selective 5-HT2A receptor inverse agonist (K_i = 2.1 nM) and 5-HT2C antagonist, a potential antipsychotic compound^[1].

All 5-HT Receptor Isoforms :

In Vivo

AC-90179 (1-10 mg/kg i.p., 30 min) completely reversed the DOI (0.3-3 mg/kg i.p., 15 min)-induced suppression of response rates, whereas at lower doses of AC-90179 (1 mg/kg i.p., 30 min), only partial reversal of DOI-induced inhibition was observed in C57BL/6 mice^[1].
AC-90179(1 or 3 mg/kg s.c.) can attenuate phencyclidine (3 mg/kg i.p., 15 min)-induced hyperactivity of NSA mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 359878-17-4
Molecular Weight 366.51
Formula C₂₃H₃₀N₂O₂
SMILES

O=C(N(CC1=CC=C(C=C1)C)C2CCN(C)CC2)CC3=CC=C(OC)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kimberly E. Vanover, et al. Pharmacological Characterization of AC-90179 [2-(4-Methoxyphenyl)-N-(4-methyl-benzyl)-N-(1-methyl-piperidin-4-yl)-acetamide Hydrochloride]: A Selective Serotonin 2A Receptor Inverse Agonist. Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 943-951

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote