2. Anti-infection
  3. Bacterial Antibiotic
  4. ADG-2e

ADG-2e is a potent antibacterial agent with MICs of 16, 4, 2, and 2 μg/mL for E. coli [KCTC 1682], P. aeruginosa [KCTC 1637], B.subtilis [KCTC 3068], and S. aureus [KCTC 1621], respectively. ADG-2e shows anti-metastatic activity against breast cancer cells.

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ADG-2e Chemical Structure

ADG-2e Chemical Structure

CAS No. : 2419951-75-8

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ADG-2e Related Antibodies

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Description

ADG-2e is a potent antibacterial agent with MICs of 16, 4, 2, and 2 μg/mL for E. coli [KCTC 1682], P. aeruginosa [KCTC 1637], B.subtilis [KCTC 3068], and S. aureus [KCTC 1621], respectively. ADG-2e shows anti-metastatic activity against breast cancer cells[1].

In Vitro

ADG-2e (1-64 μg/mL, 22 hours) exhibits twice the antibacterial activity compared to other antibiotics in methicillin-resistant S. aureus (MRSA) or multidrug-resistant P. aeruginosa (MDRPA) [1].
ADG-2e (0-60 μg/mL, 2 hours) shows only slight hemolysis with increasing concentration[1].
ADG-2e (0-100 μM, 24 hours) does not inhibit the proliferation of MDA-MB-231 cells but has a role in the migration of cancer cells by inserting into the surface of them and affecting cell motility[1].
ADG-2e (0-40 μM, 6 hours) causes actin reorganization to promote its multiple lamellar structures formation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ADG-2e Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: Sheep red blood cells (sRBCs)
Concentration: 0-60 μg/mL
Incubation Time: 2 hours
Result: Showed any hemolysis until 16 μg/mL and showed slight hemolysis at 32 μg/mL.

Cell Proliferation Assay[1]

Cell Line: Metastatic breastcancer cell line MDA-MB-231
Concentration: 0-100 μM
Incubation Time: 24 hours
Result: No significant inhibitory effect on the proliferation of MDA-MB-231 cells.

Immunofluorescence[1]

Cell Line: Metastatic breastcancer cell line MDA-MB-231
Concentration: 0-40 μM
Incubation Time: 6 hours
Result: Showed an increase in actin lamellipodium generation.
Molecular Weight

790.05

Formula

C42H67N11O4
CAS No.
SMILES

CC1=CN([C@H]2C[C@H](NC(CC34C[C@@H]5C[C@H](C3)C[C@H](C4)C5)=O)[C@@H](CNC(CC67C[C@@H]8C[C@H](C6)C[C@H](C7)C8)=O)O2)C(N=C1N(CCCNC(N)=N)CCCNC(N)=N)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ADG-2e Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ADG-2e2419951-75-8BacterialAntibioticantibacterial agentE. coliP. aeruginosaB.subtilisS. aureusanti-metastaticbreast cancerInhibitorinhibitorinhibit

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