Anticancer agent 249
Anticancer agent 249 (Compound 89) is an inhibitor for Hsp90β with IC50 of 16.5 μM in PC3MM2 cell. Anticancer agent 249 inhibits proliferation of cancer cells MCF-7, T47D, MDA-MB-231, MDA-MB-468 and SKBr3 with IC50 of 1.8-5.3 μM. Anticancer agent 249 induces apoptosis in MDA-MB-231. Anticancer agent 249 exhibits antitumor efficacy in mice.
For research use only. We do not sell to patients.
- Formula: C25H31Cl2N3O2
- Molecular Weight:476.44
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | IC50 |
3.1 μM
Compound: 89
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Anti-cancer activity against human MCF7 cells assessed as inhibition of cell viability incubated for 72 hrs by MTS assay
Anti-cancer activity against human MCF7 cells assessed as inhibition of cell viability incubated for 72 hrs by MTS assay
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[PMID: 39042910] |
| MDA-MB-468 | IC50 |
2.7 μM
Compound: 89
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Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition in cell viability measured after 72 hrs by MTS assay
Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition in cell viability measured after 72 hrs by MTS assay
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[PMID: 39042910] |
Chemical Information
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Molecular Weight 476.44
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Formula C25H31Cl2N3O2
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SMILES
ClC1=CC=C(NC(C2CCN(CC3=CC=C(OCC4CCNCC4)C=C3)CC2)=O)C=C1Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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