country

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-10363

Copy Link Print Information

AP 24149

AP 24149 is a potent Src-Abl dual inhibitor with IC₅₀ values of 9.1, 3.6 nM for Src and Abl, respectively.

For research use only. We do not sell to patients.

CAS No.: 926922-29-4
Formula: C₂₃H₂₄N₅OP
Molecular Weight:417.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

AP 24149 Chemical Structure

CAS No.: 926922-29-4

Size

Price

Stock

Quantity

Sample (0.1mg)

In-stock

(In Japan)

Apply Now

Get Quote Ask For Quote & Lead Time Consult sales personnel for more information Check price and availability Get Quote Ask For Quote & Lead Time Consult sales personnel for more information Check price and availability

Bulk Inquiry

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

AP 24149 is a potent Src-Abl dual inhibitor with IC₅₀ values of 9.1, 3.6 nM for Src and Abl, respectively^[1].

IC₅₀ & Target^[1]

Abl

3.6 nM (IC₅₀)

Src

9.1 nM (IC₅₀)

All Bcr-Abl Isoforms :

Abl
Bcr-Abl

All Src Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
BaF3	IC₅₀	168 nM Compound: 10a	Cytotoxicity against mouse BA/F3 cells transfected with wild-type Bcr-Abl Cytotoxicity against mouse BA/F3 cells transfected with wild-type Bcr-Abl	[PMID: 18691885]
K562	IC₅₀	109 nM Compound: 10a	Cytotoxicity against human K562 cells transfected with wild-type Bcr-Abl Cytotoxicity against human K562 cells transfected with wild-type Bcr-Abl	[PMID: 18691885]

Chemical Information

CAS No. 926922-29-4
Molecular Weight 417.44
Formula C₂₃H₂₄N₅OP
SMILES

O=P(C)(C)C(C=C1)=CC=C1NC2=C3N=CN(/C=C/C4=C(C)C=CC=C4C)C3=NC=N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhou T, et al. Structural analysis of DFG-in and DFG-out dual Src-Abl inhibitors sharing a common vinyl purine template. Chem Biol Drug Des. 2010 Jan;75(1):18-28. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

Get Quote In-stock

Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

AP 24149

All Bcr-Abl Isoforms

All Src Isoforms