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Cat. No.: HY-P5721

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Apidaecin IA

Apidaecin IA is a basic peptide. Apidaecin IA inhibits the enzymatic activity of DnaK. Apidaecin IA induces bacterial cell death. Apidaecin IA can be used in research related to peritonitis and bacterial infections.

For research use only. We do not sell to patients.

CAS No.: 123081-48-1
Formula: C₉₅H₁₅₀N₃₂O₂₃
Molecular Weight:2108.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Apidaecin IA Chemical Structure

CAS No.: 123081-48-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

DnaK

All HSP Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CEM-SS	EC₅₀	>47.4 μM Compound: Apidaecin IA	Antiviral activity against HIV1 3B infected in human CEM-SS cells assessed as inhibition of viral replication after 6 days by XTT assay Antiviral activity against HIV1 3B infected in human CEM-SS cells assessed as inhibition of viral replication after 6 days by XTT assay	[PMID: 20086159]

In Vitro

Apidaecin IA (100 ng/mL; 8 h) inhibits DnaK activity and binds LPS (HY-D1056), reducing bacterial survival by approximately 2 log₁₀ at 8 h post-induction^[1].
Apidaecin IA (0.02-200 μg/mL) potently inhibits the growth of a variety of Gram-negative bacterial strains, with its MIC values ranging from 0.02 μg/mL to 0.2 μg/mL^[2].
Apidaecin IA (100 μg/mL) exhibits antibacterial activity against Escherichia coli NCTC 9001 cells. It inhibits the growth of the cells without causing immediate lysis, and does not interfere with the phospholipid bilayer^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 123081-48-1
Molecular Weight 2108.41
Formula C₉₅H₁₅₀N₃₂O₂₃
Sequence

Gly-Asn-Asn-Arg-Pro-Val-Tyr-Ile-Pro-Gln-Pro-Arg-Pro-Pro-His-Pro-Arg-Ile
Sequence Shortening

GNNRPVYIPQPRPPHPRI
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Animals
honeybee
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (259 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Krom RJ, et al. Engineered Phagemids for Nonlytic, Targeted Antibacterial Therapies. Nano letters. 2015 Jul 08;15(7):4808-13. [Content Brief]

[2]. Casteels P, et al. Apidaecins: antibacterial peptides from honeybees. The EMBO journal. 1989 Aug;8(8):2387-91. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Apidaecin IA

All HSP Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Apidaecin IA Related Classifications

HY-P5721 Related Classifications