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Referencia número: HY-P5721

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Apidaecin IA

Apidaecin IA is a basic peptide. Apidaecin IA inhibits the enzymatic activity of DnaK. Apidaecin IA induces bacterial cell death. Apidaecin IA can be used in research related to peritonitis and bacterial infections.

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No. CAS: 123081-48-1
Fòrmula: C₉₅H₁₅₀N₃₂O₂₃
Peso molecular:2108.41

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Apidaecin IA Chemical Structure

No. CAS: 123081-48-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
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Actividad biológica

Descripciòn

IC₅₀ & Target

DnaK

Ver todos los productos específicos de isoformas HSP :

Cellular Effect

Cell Line	Type	Value	Description	References
CEM-SS	EC₅₀	>47.4 μM Compound: Apidaecin IA	Antiviral activity against HIV1 3B infected in human CEM-SS cells assessed as inhibition of viral replication after 6 days by XTT assay Antiviral activity against HIV1 3B infected in human CEM-SS cells assessed as inhibition of viral replication after 6 days by XTT assay	[PMID: 20086159]

In Vitro

Bacterial Infection

Apidaecin IA (100 ng/mL; 8 h) acetate inhibits DnaK activity and binds LPS (HY-D1056), reducing bacterial survival by approximately 2 log₁₀ at 8 h post-induction^[1].
Apidaecin IA (0.02-200 μg/mL) acetate potently inhibits the growth of a variety of Gram-negative bacterial strains, with its MIC values ranging from 0.02 μg/mL to 0.2 μg/mL^[2].
Apidaecin IA (100 μg/mL) acetate exhibits antibacterial activity against Escherichia coli NCTC 9001 cells. It inhibits the growth of the cells without causing immediate lysis, and does not interfere with the phospholipid bilayer^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

No. CAS 123081-48-1
Peso molecular 2108.41
Fòrmula C₉₅H₁₅₀N₃₂O₂₃
Sequence

Gly-Asn-Asn-Arg-Pro-Val-Tyr-Ile-Pro-Gln-Pro-Arg-Pro-Pro-His-Pro-Arg-Ile
Sequence Shortening

GNNRPVYIPQPRPPHPRI
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Animal
honeybee
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (259 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Krom RJ, et al. Engineered Phagemids for Nonlytic, Targeted Antibacterial Therapies. Nano letters. 2015 Jul 08;15(7):4808-13. [Content Brief]

[2]. Casteels P, et al. Apidaecins: antibacterial peptides from honeybees. The EMBO journal. 1989 Aug;8(8):2387-91. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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