UBP 1112
UBP 1112 is a selective group III mGluR antagonist, with a Kd of 5.1 μM.UBP 1112 shows 96-fold affinity for group III over group II mGlu receptor (Kd, 488 μM), and shows no significant activity at group I mGlu receptor or iGlu receptor.
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- CAS. Nr.: 339526-74-8
- Formel: C10H14NO5P
- Molecular Weight:259.20
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
Kd: 5.1 μM (group III mGluR), 488 μM (group II mGluR)[1]
UBP 1112 antagonises the depression of the fast component of the dorsal root-evoked ventral root potential induced by (S)-AP4 with apparent KD of 5.1 μM. UBP 1112 also antagonises the (S)-AP4 induced depression of synaptic transmission, with pA2 of 5.3. In addition, UBP 1112 (1 mM) displays little or no activity on (S)-3,5-DHPG-, NMDA-, AMPA- or kainate-induced responses on motoneurones[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 339526-74-8
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Molecular Weight 259.20
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Formel C10H14NO5P
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SMILES
OC(C(N)(C1=CC(C)=C(P(O)(O)=O)C=C1)C)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
UBP 1112 Related Classifications
HY-107517 Related Classifications
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