AA-17010
AA-17010 is a Cereblon ligand with an IC50 of 0.20 μM and a Ki of 0.08 μM. AA-17010 serves as an E3 ligase ligand for the synthesis of PROTAC KRAS degraders, such as CW-10201 (HY-189305).
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- CAS. Nr.: 3064305-88-7
- Formel: C19H22N4O4
- Molecular Weight:370.40
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
Cereblon 0.20 μM (IC50) |
In Vitro
AA-17010 (~3 h) is a high-affinity Cereblon ligand that binds to CRBN with an IC50 of 0.20 μM and a Ki of 0.08 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS. Nr. 3064305-88-7
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Molecular Weight 370.40
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Formel C19H22N4O4
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SMILES
O=C(C(N(C(N(C)C1=C2)=O)C1=CC3=C2C4(CCNCC4)CO3)CC5)NC5=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
AA-17010 Related Classifications
HY-189348 Related Classifications
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