Cinanserin
Based on 1 publication(s) in Google Scholar
Cinanserin (SQ 10643) is a potent and selective 5-HT2 antagonist with Ki values of 41, 3500 nM for 5-HT2, 5-HT1, respectively. Cinanserin also is a SARS-CoV 3CLpro inhibitor with an KD value of 49.4, 18.2 µM for SARS-CoV 3CLpro, HCoV-229E 3CLpro, respectively. Cinanserin reduces systemic burn edema levels.
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- CAS. Nr.: 1166-34-3
- Formel: C20H24N2OS
- Molecular Weight:340.48
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Cinanserin
MoreAlle 5-HT Receptor Isoform-spezifische Produkte anzeigen
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Biologische Aktivität
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5-HT2 Receptor 41 nM (Ki) |
5-HT1 Receptor 3500 nM (Ki) |
SARS-CoV 3CLpro 49.4 μM (Kd) |
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Cell Line
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Type | Value | Description | References |
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| Vero | CC50 |
31 μM
Compound: 8
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Cytotoxicity against african green monkey Vero E6 cells after 48 hrs by CellTiter-Glo luminescent cell viability assay
Cytotoxicity against african green monkey Vero E6 cells after 48 hrs by CellTiter-Glo luminescent cell viability assay
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[PMID: 23231439] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar rats (250 g) underwent thermal injury[1]
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Dosage:5 mg/kg
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Administration:Intravenous injection; for 2 hours
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Result:Significantly reduced systemic burn edema to shamburn levels, leukocyte-endothelial interactions are significantly reduced by administration of Cinanserin.
Chemical Information
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CAS. Nr. 1166-34-3
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Molecular Weight 340.48
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Formel C20H24N2OS
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SMILES
O=C(NC1=CC=CC=C1SCCCN(C)C)/C=C/C2=CC=CC=C2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Sci Rep
Hepatitis C virus NS3/4A inhibitors and other drug-like compounds as covalent binders of SARS-CoV-2 main protease. [Abstract]2022 Jul 16;12(1):12197. PMID: 35842458
Reinheit & Dokumentation
Verweise
[1]. Hernekamp JF, et al. Cinanserin reduces plasma extravasation after burn plasma transfer in rats. Burns. 2013 Sep;39(6):1226-33. [Content Brief]
[2]. Chen L, et al. Cinanserin is an inhibitor of the 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro. J Virol. 2005 Jun;79(11):7095-103. [Content Brief]
[3]. Leysen, J. E., et al. Receptor binding profile of R 41 468, A novel antagonist at 5-HT2 receptors. Life Sciences, 1981, 28(9), 1015-1022. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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