Art. -Nr.: HY-116392B

DL-threo-PDMP hydrochloride

Name: DL-threo-PDMP hydrochloride
Brand: MedChemExpress
SKU: HY-116392B
Price: 90.00 USD
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DL-threo-PDMP hydrochloride is a competitive glucosylceramide synthase (GCS) inhibitor and antimalarial agent. DL-threo-PDMP hydrochloride competitively inhibits the activity of GCS. DL-threo-PDMP hydrochloride restores cisplatin sensitivity in cisplatin-resistant testicular germ cell tumor cells. DL-threo-PDMP hydrochloride blocks the growth of ring-stage Plasmodium falciparum parasites.

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Reinheit : 99.40%
CAS. Nr.: 80938-69-8
Formel: C₂₃H₃₉ClN₂O₃
Molecular Weight:427.02

Speicherung:

-20°C, stored under nitrogen, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

DL-threo-PDMP hydrochloride Chemical Structure

CAS. Nr.: 80938-69-8

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

Plasmodium

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In Vitro

DL-threo-PDMP (30 μmol/L; 48 h) hydrochloride restores cisplatin sensitivity in cisplatin-resistant SuSaR testicular germ cell tumor cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Cell Viability Assay^[1]

View Protocol

Cell Line:

SuSaR (cisplatin-resistant human nonseminomatous testicular germ cell teratocarcinoma cell line)
Concentration:

30 μmol/L (combined with cisplatin treatment)
Incubation Time:

48 h (combined with cisplatin treatment)
Result:

Reduced the cisplatin IC₅₀ in SuSaR cells from 2.72 ± 0.16 μg/mL to 1.22 ± 0.22 μg/mL, resulting in 44.8% cisplatin resensitization.
Significantly increased intracellular ceramide levels in SuSaR cells compared to control, cisplatin alone, or DL-threo-PDMP alone.

In Vivo

DL-threo-PDMP (hydrochloride) (50 mg/kg; i.p.; daily; 21 days) alone does not reduce cisplatin-refractory testicular germ cell tumor weight in nude mice, but when combined with cisplatin (3.5 mg/kg; i.v.; once weekly; 3 consecutive weeks), it resensitizes the tumors, producing 42.8% to 73.5% tumor weight reduction and a 2.7- to 2.81-fold increase in apoptosis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Nude mice^[1]
Dosage:

50 mg/kg (single agent; combined with cisplatin 3.5 mg/kg)
Administration:

i.p.; daily; 21 days; 1 hour before cisplatin (i.v.; once weekly; 3 consecutive weeks) for combined group
Result:

Did not produce a significant reduction in tumor weight compared to vehicle-treated animals as a single agent.
Produced significant tumor weight reductions of 42.8% in TGT1XR tumors and 73.5% in TGT38XR tumors compared to vehicle controls when combined with cisplatin.
Induced a 2.7-fold increase in apoptotic cells (caspase-3 positive) in TGT1XR tumors and a 2.81-fold increase in TGT38XR tumors compared to cisplatin-only treatment when combined with cisplatin.

Chemical Information

CAS. Nr. 80938-69-8
Appearance Solid
Molecular Weight 427.02
Formel C₂₃H₃₉ClN₂O₃
Color White to off-white
SMILES

O[C@H](C1=CC=CC=C1)[C@H](NC(CCCCCCCCC)=O)CN2CCOCC2.Cl
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

-20°C, stored under nitrogen, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (234.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.3418 mL

11.7091 mL

23.4181 mL

5 mM

0.4684 mL

2.3418 mL

4.6836 mL

10 mM

0.2342 mL

1.1709 mL

2.3418 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Piulats JM, et al. Orthoxenografts of Testicular Germ Cell Tumors Demonstrate Genomic Changes Associated with Cisplatin Resistance and Identify PDMP as a Resensitizing Agent. Clin Cancer Res. 2018;24(15):3755-3766. [Content Brief]

[2]. Lauer SA, et al. Sphingolipid synthesis as a target for chemotherapy against malaria parasites. Proc Natl Acad Sci U S A. 1995;92(20):9181-9185. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.3418 mL	11.7091 mL	23.4181 mL	58.5453 mL
	5 mM	0.4684 mL	2.3418 mL	4.6836 mL	11.7091 mL
	10 mM	0.2342 mL	1.1709 mL	2.3418 mL	5.8545 mL
	15 mM	0.1561 mL	0.7806 mL	1.5612 mL	3.9030 mL
	20 mM	0.1171 mL	0.5855 mL	1.1709 mL	2.9273 mL
	25 mM	0.0937 mL	0.4684 mL	0.9367 mL	2.3418 mL
	30 mM	0.0781 mL	0.3903 mL	0.7806 mL	1.9515 mL
	40 mM	0.0585 mL	0.2927 mL	0.5855 mL	1.4636 mL
	50 mM	0.0468 mL	0.2342 mL	0.4684 mL	1.1709 mL
	60 mM	0.0390 mL	0.1952 mL	0.3903 mL	0.9758 mL
	80 mM	0.0293 mL	0.1464 mL	0.2927 mL	0.7318 mL
	100 mM	0.0234 mL	0.1171 mL	0.2342 mL	0.5855 mL

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DL-threo-PDMP hydrochloride

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