Art. -Nr.: HY-122422

Gepirone

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Gepirone is a selective and affinitive 5-HT_1A agonist. Gepirone binds selectively to 5-HT_1A receptor binding site. Gepirone acts as an antidepressant agent can be used for anxiety and major depressive disorder research.

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Reinheit: 99.88%
CAS. Nr.: 83928-76-1
Formel: C₁₉H₂₉N₅O₂
Molecular Weight:359.47

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Gepirone Chemical Structure

CAS. Nr.: 83928-76-1

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
- Clinical Trial
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

5-HT_1A Receptor

Alle 5-HT Receptor Isoform-spezifische Produkte anzeigen :

In Vivo

Gepirone (0-3 mg/kg for intraperitoneal injection) interacts with progesterone at 5-HT_1A receptors to reduce lordosis behavior in female rats treated with estradiol benzoate and progesterone^[1].
Gepirone (10, 15 mg/kg for subcutaneous injection, 2, 7, or 14 days) activates the normosensitive postsynaptic 5-HT_1A receptor in Male Sprague-Dawley rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley rats^[1]
Dosage:

0, 0.1, 0.3, 1 and 3 mg/kg
Administration:

Intraperitoneal injection (i.p.)
Result:

Increases in lordotic activity at lower doses.
Inhibited lordosis by the 0.3 and 1.0 mg/kg doses and further inhibition was produced by the 3.0 mg/kg dose.

Animal Model:

Male Sprague-Dawley rats^[2]
Dosage:

10, 15 mg/kg
Administration:

Subcutaneous injection (s.c.)
Result:

Decreased the number of spontaneously active 5-HT neurons and firing rate.
Not modified with long-term treatment with ED₅₀ value of 10.1±0.5 μg/kg in controls and 9.7 ±1.9 μg/kg in treated rats.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 83928-76-1
Appearance Solid
Molecular Weight 359.47
Formel C₁₉H₂₉N₅O₂
Color White to light yellow
SMILES

O=C(CC(C)(C)C1)N(CCCCN2CCN(C3=NC=CC=N3)CC2)C1=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Lösungsmittel & Löslichkeit

In Vitro:

Ethanol : 33.33 mg/mL (92.72 mM; Need ultrasonic)

DMSO : 33.33 mg/mL (92.72 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.7819 mL

13.9094 mL

27.8187 mL

5 mM

0.5564 mL

2.7819 mL

5.5637 mL

10 mM

0.2782 mL

1.3909 mL

2.7819 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Mendelson SD, et al. Effects of 5-HT1A selective anxiolytics on lordosis behavior: interactions with progesterone. Eur J Pharmacol. 1986 Dec 16;132(2-3):323-6. [Content Brief]

[2]. Blier P, et al. Modification of 5-HT neuron properties by sustained administration of the 5-HT1A agonist gepirone: electrophysiological studies in the rat brain. Synapse. 1987;1(5):470-80. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
Ethanol / DMSO	1 mM	2.7819 mL	13.9094 mL	27.8187 mL	69.5468 mL
	5 mM	0.5564 mL	2.7819 mL	5.5637 mL	13.9094 mL
	10 mM	0.2782 mL	1.3909 mL	2.7819 mL	6.9547 mL
	15 mM	0.1855 mL	0.9273 mL	1.8546 mL	4.6365 mL
	20 mM	0.1391 mL	0.6955 mL	1.3909 mL	3.4773 mL
	25 mM	0.1113 mL	0.5564 mL	1.1127 mL	2.7819 mL
	30 mM	0.0927 mL	0.4636 mL	0.9273 mL	2.3182 mL
	40 mM	0.0695 mL	0.3477 mL	0.6955 mL	1.7387 mL
	50 mM	0.0556 mL	0.2782 mL	0.5564 mL	1.3909 mL
	60 mM	0.0464 mL	0.2318 mL	0.4636 mL	1.1591 mL
	80 mM	0.0348 mL	0.1739 mL	0.3477 mL	0.8693 mL

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Gepirone

Neurotransmitter Receptor Compound Library

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Anti-Alzheimer's Disease Compound Library

Antidepressant Compound Library

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Bioactive Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

Lactylation Compound Library

GPCR/G Protein Compound Library

Neuronal Signaling Compound Library

FDA-Approved Drug Library

Drug Repurposing Compound Library

Alle 5-HT Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Gepirone

Neurotransmitter Receptor Compound Library

FDA Approved & Pharmacopeial Drug Library

Anti-Alzheimer's Disease Compound Library

Antidepressant Compound Library

Human Metabolite Library

Coagulation and Anti-coagulation Compound Library

Off-patent Drug Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Drug Repurposing Compound Library Plus

FDA-Approved Drug Library Plus

FDA-Approved Drug Library Mini

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

Lactylation Compound Library

GPCR/G Protein Compound Library

Neuronal Signaling Compound Library

FDA-Approved Drug Library

Drug Repurposing Compound Library

Alle 5-HT Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Gepirone Related Classifications

HY-122422 Related Classifications