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Art. -Nr.: HY-147196

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KB03-SLF

KB03-SLF is a bifunctional PROTAC, formed by conjugating the cysteine-targeting KB03 exploratory fragment with SLF (HY-114872), an FKBP12 ligand that does not support the degradation of FKBP12^NLS. KB03-SLF fails to degrade nuclear-localized FKBP12^NLS in cells, nor can it mediate the interaction between DCAF16 and FKBP12^NLS in a manner similar to KB02-SLF (HY-129610).
(Pink: FKBP51 and FKBP12 ligand (HY-114872); Blue: Cereblon ligand (HY-169968); Black: linker (HY-W040168)).

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CAS. Nr.: 2384184-42-1
Formel: C₅₀H₆₃ClF₃N₅O₁₂
Molecular Weight:1018.51

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

KB03-SLF Chemical Structure

CAS. Nr.: 2384184-42-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- In Vitro
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Beschreibung

KB03-SLF is a bifunctional PROTAC, formed by conjugating the cysteine-targeting KB03 exploratory fragment with SLF (HY-114872), an FKBP12 ligand that does not support the degradation of FKBP12^NLS. KB03-SLF fails to degrade nuclear-localized FKBP12^NLS in cells, nor can it mediate the interaction between DCAF16 and FKBP12^NLS in a manner similar to KB02-SLF (HY-129610)^[1]. (Pink: FKBP51 and FKBP12 ligand (HY-114872); Blue: Cereblon ligand (HY-169968); Black: linker (HY-W040168)).

IC₅₀ & Target

^[1]

FKBP12

Cereblon

Alle PROTACs Isoform-spezifische Produkte anzeigen :

In Vitro

KB03-SLF (2 µM; 8-24 h) does not support DCAF16-mediated degradation of nuclear-localized FLAG-FKBP12_NLS in HEK293T cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Western Blot Analysis^[1]

View Protocol

Cell Line:

HEK293T cells stably expressing nuclear-localized FLAG-FKBP12_NLS
Concentration:

5 µM
Incubation Time:

2 h
Result:

Did not promote degradation of nuclear-localized FLAG-FKBP12_NLS.
Did not induce KB02-SLF-dependent enrichment of DCAF16 with FLAG-FKBP12_NLS in co-immunoprecipitation experiments.

Chemical Information

CAS. Nr. 2384184-42-1
Molecular Weight 1018.51
Formel C₅₀H₆₃ClF₃N₅O₁₂
SMILES

O=C([C@H]1N(CCCC1)C(C(C(C)(C)CC)=O)=O)O[C@@H](C2=CC(NC(CCOCCOCCNC(CCNC(C3=CC(NC(CCl)=O)=CC(C(F)(F)F)=C3)=O)=O)=O)=CC=C2)CCC4=CC(OC)=C(C=C4)OC
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Zhang X, et al. Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16. Nature chemical biology. 2019 Jul;15(7):737-746. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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KB03-SLF

Alle PROTACs Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Beschreibung

IC50 & Target

In Vitro

Chemical Information

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KB03-SLF Related Classifications

HY-147196 Related Classifications

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