Lecankitug
Based on 1 Customer Validation
Lecankitug (LZM-012) is a humanized IgG1κ monoclonal antibody targeting IL-17A/F. Lecankitug exerts immunosuppressive and anti-inflammatory activities. Lecankitug can be used in the research of autoimmune and inflammatory diseases, such as psoriasis, ankylosing spondylitis, and rheumatoid arthritis.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 98%
- CAS. Nr.: 2923284-76-6
- Molecular Weight:146.514 kDa
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biologische Aktivität
Beschreibung
Isotype
Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
[1]|
IL-17A |
IL-17F |
In Vitro
IL-17A/F are proinflammatory cytokines involved in the pathological processes of autoimmune diseases such as psoriasis and ankylosing spondylitis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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IgG1-kappa
Anwendung
ELISA, FACS, Functional assay
Verified Bioactivity
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Loaded Lecankitug on ProA biosensor, can bind HY-P70527 IL-17A Protein, Human (HEK293, His) with an affinity constant of 3.464E-10 M as determined in BLI assay. -
Loaded Lecankitug on ProA biosensor, can bind HY-P72586 IL-17F Protein, Human (HEK293) with an affinity constant of 1.853E-09 M as determined in BLI assay.
Chemical Information
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CAS. Nr. 2923284-76-6
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Appearance Liquid
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Molecular Weight 146.514 kDa
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Color Colorless to light yellow
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SMILES
N/A
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Synonyms
LZM-012; XKH004
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Versand
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
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Data Sheet (256 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)