MKC-1
Based on 1 Customer Validation
MKC-1 (Ro-31-7453) is an orally active and potent cell cycle inhibitor with broad antitumor activity. MKC-1 inhibits the Akt/mTOR pathway. MKC-1 arrests cellular mitosis and induces cell apoptosis by binding to a number of different cellular proteins including tubulin and members of the importin β family.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.78%
- CAS. Nr.: 125313-92-0
- Formel: C22H16N4O4
- Molecular Weight:400.39
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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HY-13691R
MKC-1 (Standard)
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HY-114384
Mefluleucine
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HY-124798
Rheb inhibitor NR1
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HY-N0656A
(+)-Usnic acid
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HY-100026
PQR620
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HY-10218S
Everolimus-d4
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HY-137175
TMBIM6 antagonist-1
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HY-111508
PI3K/mTOR Inhibitor-2
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HY-13260A
CCT128930 hydrochloride
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HY-124036
DS-7423
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HY-10250
Triciribine phosphate
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HY-N0656AR
(+)-Usnic acid (Standard)
Biologische Aktivität
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 125313-92-0
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Appearance Solid
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Molecular Weight 400.39
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Formel C22H16N4O4
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Color Orange to red
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SMILES
O=C(C(C1=CN(C)C2=C1C=CC=C2)=C3C4=CN(C)C5=C4C=CC([N+]([O-])=O)=C5)NC3=O
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Synonyms
Ro-31-7453
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : ≥ 50 mg/mL (124.88 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (283 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Wang M, et al. The first design and synthesis of [11C]MKC-1 ([11C]Ro 31-7453), a new potential PET cancer imaging agent. Nucl Med Biol. 2010 Oct;37(7):763-75. [Content Brief]
[2]. Faris JE, et al. A phase 2 study of oral MKC-1, an inhibitor of importin-β, tubulin, and the mTOR pathway in patients with unresectable or metastatic pancreatic cancer. Invest New Drugs. 2012 Aug;30(4):1614-20. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4976 mL | 12.4878 mL | 24.9756 mL | 62.4391 mL |
| 5 mM | 0.4995 mL | 2.4976 mL | 4.9951 mL | 12.4878 mL | |
| 10 mM | 0.2498 mL | 1.2488 mL | 2.4976 mL | 6.2439 mL | |
| 15 mM | 0.1665 mL | 0.8325 mL | 1.6650 mL | 4.1626 mL | |
| 20 mM | 0.1249 mL | 0.6244 mL | 1.2488 mL | 3.1220 mL | |
| 25 mM | 0.0999 mL | 0.4995 mL | 0.9990 mL | 2.4976 mL | |
| 30 mM | 0.0833 mL | 0.4163 mL | 0.8325 mL | 2.0813 mL | |
| 40 mM | 0.0624 mL | 0.3122 mL | 0.6244 mL | 1.5610 mL | |
| 50 mM | 0.0500 mL | 0.2498 mL | 0.4995 mL | 1.2488 mL | |
| 60 mM | 0.0416 mL | 0.2081 mL | 0.4163 mL | 1.0407 mL | |
| 80 mM | 0.0312 mL | 0.1561 mL | 0.3122 mL | 0.7805 mL | |
| 100 mM | 0.0250 mL | 0.1249 mL | 0.2498 mL | 0.6244 mL |
MKC-1 Related Classifications
HY-13691 Related Classifications
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