MS-1020
MS-1020 is a potent and ATP-competitive JAK3 inhibitor. MS-1020 inhibits JAK3/STAT signaling and induces apoptosis. MS-1020 promotes cell death. MS-1020 decreases the expression of tyrosine phosphorylated STAT3 levels. MS-1020 has the potential for the research of cancers harboring aberrant JAK3 signaling.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 1255516-86-9
- Formel: C21H18N2O3
- Molecular Weight:346.38
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Biologische Aktivität
|
JAK3 |
MS-1020 (0-50 µM; 24 h) inhibits STAT92E transcriptional activity in cultured Drosophila cells[1].
MS-1020 (0, 10, 30 , 50 µM) decreases the expression of tyrosine phosphorylated STAT3 levels and shows no changes on total STAT3 levels[1].
MS-1020 (0, 10, 30 , 50 µM; 16 h) decreases the expression of IL-2 (100 ng/ml)-induced STAT5 phosphorylation in Nb2 cells[1].
MS-1020 (0, 10, 30 , 50 µM; 72 h) promotes cell death in a time- and dose-dependent manner in L540 cells[1].
MS-1020 (0, 10, 30 , 50 µM; 72 h) induces apoptosis in L540 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:L540, HDLM-2, MDA-MB-468 cells
-
Concentration:0, 10, 30, 50 µM
-
Incubation Time:
-
Result:Decreased the expression of tyrosine phosphorylated STAT3 levels in a dose-dependent manner and showed no changes on total STAT3 levels.
-
Cell Line:L540, HDLM-2 cells
-
Concentration:0, 10, 30, 50 µM
-
Incubation Time:72 h
-
Result:Promoted cell death in a time- and dose-dependent manner only in L540 cells.
-
Cell Line:L540 cells
-
Concentration:0, 10, 30, 50 µM
-
Incubation Time:72 h
-
Result:Induced apoptosis in L540 cells and increased the expression of cleavage of Poly (ADP-ribose) polymerase (PARP) and cleaved caspase-3 and cleaved caspase-3, decreased the expression of Bcl-2, Bcl-xL, Mcl-1, and survivin in a dose-dependent manner.
Chemical Information
-
CAS. Nr. 1255516-86-9
-
Molecular Weight 346.38
-
Formel C21H18N2O3
-
SMILES
O=C(C1=CC=C2C=CC=CC2=C1O)NCCC3=CNC4=C3C=C(O)C=C4
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
MS-1020 Related Classifications
HY-123099 Related Classifications
Powered by Bioz