MS8572
MS8572 is a selective OTUB1 covalent ligand. MS8572 covalently modifies the noncatalytic cysteine 23 residue of OTUB1 and does not inhibit OTUB1 deubiquitinase activity. MS8572 can be used for development of deubiquitinase-targeting chimeras for targeted protein stabilization.
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- CAS. Nr.: 3060517-63-4
- Formel: C17H23N3O2S
- Molecular Weight:333.45
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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OTUB1 |
MS8572 covalently modifies purified wild-type human OTUB1 protein, with a modification efficiency of 78%-84% when incubated at a ligand-to-protein ratio of 250:1 for 1 h, and does not inhibit the deubiquitinase activity of purified human OTUB1 protein[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 3060517-63-4
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Molecular Weight 333.45
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Formel C17H23N3O2S
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SMILES
CC1=CC=C(S1)C(N2CC3CC(C2)N3C(/C=C/CN(C)C)=O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
MS8572 Related Classifications
HY-183724 Related Classifications
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