NXP800
Based on 4 publication(s) in Google Scholar
NXP800 (CCT361814) is a potent and orally active heat shock factor 1 (HSF1) pathway inhibitor. NXP800 has the potential for cancer research.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.86%
- CAS. Nr.: 1693734-80-3
- Formel: C32H32FN5O4
- Molecular Weight:569.63
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Publications Citing Use of MedChemExpress (MCE) NXP800
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Customer Validation & Images
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Apoptosis Analysis
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IHC
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Cell Proliferation/Viability Assay
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WB
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IF
Biologische Aktivität
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HSF1 |
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Cell Line
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Type | Value | Description | References |
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| SK-OV-3 | GI50 |
8.5 nM
Compound: 22; CCT361814
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Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition measured after 96 hrs by resazurin dye based celltiter-blue viability assay
Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition measured after 96 hrs by resazurin dye based celltiter-blue viability assay
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[PMID: 37017629] |
| SK-OV-3 | IC50 |
94 nM
Compound: 22; CCT361814
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Inhibition of 17-AAG induced HSP72-expression in human SK-OV-3 cells incubated for 18 hrs by ELISA
Inhibition of 17-AAG induced HSP72-expression in human SK-OV-3 cells incubated for 18 hrs by ELISA
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[PMID: 37017629] |
NXP800 (example 169) inhibits U20S cells viability (IC50=0.056 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Pharmacokinetic Analysis[2]
| Species | Route | Dose (mg/kg) | Tmax (h) | AUClast (ng·h/mL) | Cltb (mL/min/kg) | t1/2 (h) | F (%) | AUCu0-t (h·nM) | Free Cav0-24h (nM) | Clu (mL/min/kg) |
| mouse | po/iv | 5/5 | 2.0 | 6000 (7800-4600) (po) | 10 (10-9.7) (iv) | 4.0 | 42 (po) | 72 | 3.3 | 830 (iv) |
| rat | po/iv | 5/1 | 6.0 | 2600 (po) | 24 (iv) | 3.1 | 45 (po) | 86 | 3.7 | 730 (iv) |
| dog | po/iv | 2.5/0.5 | 2.0 | 250 (po) | 21 (iv) | 1.4 | 9.1 (po) | 35 | 1.9 | 150 (iv) |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 1693734-80-3
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Appearance Solid
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Molecular Weight 569.63
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Formel C32H32FN5O4
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Color Light yellow to green yellow
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SMILES
O=C(C1=CC=C2OCCOC2=C1)NC3=CC=C(C(NC(C4=CC5=C(N=C(CN6CCN(CC6)CC)C=C5)C=C4)=O)=C3)F
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Synonyms
CCT361814
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (4)
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Journal Impact Factor
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Most Recent
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Int J Mol Sci
The Novel HSF1 Inhibitor NXP800 Exhibits Robust Antitumor Activity in Hepatocellular Carcinoma. [Abstract]2026 Mar 19;27(6):2781. PMID: 41898642
NXP800 purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2026 Mar 19;27(6):2781. [Abstract]
Cells treated with NXP800 at 50 nM concentration, either alone or in association with 5 OLA. Apoptosis was assessed in HLF.
NXP800 purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2026 Mar 19;27(6):2781. [Abstract]
The P151 and P558 patient-derived organoids (PDOs) were treated with 500 nM NXP800 for 48 h, and levels of the proliferation marker Ki67, the apoptosis marker cleaved caspase 3, and the DNA damage marker phosphorylated/activated (p) histone H2A.X were evaluated immunohistochemically.
NXP800 purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2026 Mar 19;27(6):2781. [Abstract]
HCC PDOs were treated with NXP800 for 48 h, and cell viability was evaluated via CellTiter-Glo®3D Luminescent Cell Viability Assay.
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Int J Mol Sci
The Role of Heat Shock Factor 1 in Preserving Proteomic Integrity During Copper-Induced Cellular Toxicity. [Abstract]2024 Oct 30;25(21):11657. PMID: 39519208
NXP800 purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2024 Oct 30;25(21):11657. [Abstract]
MIA PaCa-2 cells treated with the indicated dose of NXP800 (0, 25, 50 nM) for 24 h. Protein levels were detected by using Western blotting.
NXP800 purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2024 Oct 30;25(21):11657. [Abstract]
MIA PaCa-2 cells were treated with 25 nM NXP800 for 2 h, followed by 1 mM CuCl2 for 24 h. Aggresomes were imaged using a fluorescence microscope.
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bioRxiv
A dietary pan-amino acid dropout screen in vivo reveals a critical role for histidine in T-ALL. [Abstract]2025 Dec 23:2025.12.21.694897. PMID: 41509383
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (175.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (272 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7555 mL | 8.7776 mL | 17.5553 mL | 43.8881 mL |
| 5 mM | 0.3511 mL | 1.7555 mL | 3.5111 mL | 8.7776 mL | |
| 10 mM | 0.1756 mL | 0.8778 mL | 1.7555 mL | 4.3888 mL | |
| 15 mM | 0.1170 mL | 0.5852 mL | 1.1704 mL | 2.9259 mL | |
| 20 mM | 0.0878 mL | 0.4389 mL | 0.8778 mL | 2.1944 mL | |
| 25 mM | 0.0702 mL | 0.3511 mL | 0.7022 mL | 1.7555 mL | |
| 30 mM | 0.0585 mL | 0.2926 mL | 0.5852 mL | 1.4629 mL | |
| 40 mM | 0.0439 mL | 0.2194 mL | 0.4389 mL | 1.0972 mL | |
| 50 mM | 0.0351 mL | 0.1756 mL | 0.3511 mL | 0.8778 mL | |
| 60 mM | 0.0293 mL | 0.1463 mL | 0.2926 mL | 0.7315 mL | |
| 80 mM | 0.0219 mL | 0.1097 mL | 0.2194 mL | 0.5486 mL | |
| 100 mM | 0.0176 mL | 0.0878 mL | 0.1756 mL | 0.4389 mL |
NXP800 Related Classifications
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