PA-082
PA-082 is a selective PPAR-γ modulator that functions as a partial agonist. PA-082 causes partial recruitment of SRC1, TIF2, SRC3 and full recruitment of PGC1-α to PPAR-γ ligand-binding domain. PA-082 prevents triglyceride accumulation during de novo adipogenesis and antagonizes Rosiglitazone (HY-17386)-induced lipid accumulation. PA-082 potentiates insulin-stimulated glucose uptake in adipocytes and protects against TNFα-induced insulin resistance. PA-082 can be used for the research of type 2 diabetes.
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- CAS. Nr.: 95520-87-9
- Formel: C33H38N2O5
- Molecular Weight:542.68
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Beschreibung
IC50 & Target
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PPAR-γ |
In Vitro
Chemical Information
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CAS. Nr. 95520-87-9
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Molecular Weight 542.68
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Formel C33H38N2O5
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SMILES
N=1C=C(C=2C=C(OC)C(OC)=CC2C1CC3=CC=C(OC)C(OC)=C3)CN4CCC(C=5C=CC=CC5OC)CC4
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
PA-082 Related Classifications
HY-180398 Related Classifications
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