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Pilocarpine

45 Cited Publications
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Based on 45 publication(s) in Google Scholar

Pilocarpine is a selective M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.

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  • Reinheit: 99.89%
  • CAS. Nr.: 92-13-7
  • Formel: C11H16N2O2
  • Molecular Weight:208.26
  • Speicherung:

    -20°C, protect from light

    * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

  • Pilocarpine Chemical Structure
    Pilocarpine Chemical Structure
  • Experimental Validation Results for Pilocarpine
  • Experimental Validation Results for Pilocarpine
  • Experimental Validation Results for Pilocarpine
  • Experimental Validation Results for Pilocarpine
  • Experimental Validation Results for Pilocarpine
  • Experimental Validation Results for Pilocarpine
  • Experimental Validation Results for Pilocarpine
  • Experimental Validation Results for Pilocarpine
  • Experimental Validation Results for Pilocarpine
  • Experimental Validation Results for Pilocarpine
  • Experimental Validation Results for Pilocarpine
  • Experimental Validation Results for Pilocarpine
CAS. Nr.: 92-13-7
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  • Pilocarpine Chemical Structure
    Pilocarpine Chemical Structure
    1/16
  • 1/16

    Pilocarpine purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 May 5;23(1):332. [Abstract]

    Customer Validation
     Seizure scores across different groups of the Pilocarpine (300 mg/kg; i.p.)-induced SE model.

  • 1/16

    Pilocarpine purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 May 5;23(1):332. [Abstract]

    Customer Validation
     Survival rate analysis among groups of the Pilocarpine (300 mg/kg; i.p.)-induced SE model.

  • 1/16

    Pilocarpine purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 May 5;23(1):332. [Abstract]

    Customer Validation
     Immunofluorescence staining of CD86 (pro-inflammatory) and CD206 (anti-inflammatory) expression in microglia within the hippocampus across groups of the Pilocarpine (300 mg/kg; i.p.)-induced SE model.

  • 1/16

    Pilocarpine purchased from MedChemExpress. Usage Cited in: Cells. 2024 Oct 1;13(19):1635. [Abstract]

    Customer Validation
     Mice were intravenously injected with Evans blue or sulfonyl-NHS-biotin tracer, followed by intraperitoneal injection of scopolamine, and finally Pilo (300 mg/kg, ip, single dose) was injected to induce epileptic seizures, with close monitoring. The results indicated increased blood-brain barrier permeability in this Pilo-induced epilepsy model.

  • 1/16

    Pilocarpine purchased from MedChemExpress. Usage Cited in: Cells. 2024 Oct 1;13(19):1635. [Abstract]

    Customer Validation
     Mice were intravenously injected with Evans blue or sulfonyl-NHS-biotin tracer, followed by intraperitoneal injection of scopolamine, and finally Pilo (300 mg/kg, ip, single dose) was injected to induce epileptic seizures, with close monitoring. The results indicated increased blood-brain barrier permeability in this Pilo-induced epilepsy model.

  • 1/16

    Pilocarpine purchased from MedChemExpress. Usage Cited in: Cells. 2024 Oct 1;13(19):1635. [Abstract]

    Customer Validation
     Mice were intravenously injected with Evans blue or sulfonyl-NHS-biotin tracer, followed by intraperitoneal injection of scopolamine, and finally Pilo (300 mg/kg, ip, single dose) was injected to induce epileptic seizures, with close monitoring. The results indicated increased blood-brain barrier permeability in this Pilo-induced epilepsy model.

  • 1/16

    Pilocarpine purchased from MedChemExpress. Usage Cited in: Cell Rep. 2023 Apr 30;42(5):112456. [Abstract]

    Customer Validation
     Latency before the first seizure of PTZ and Pilocarpine ((300 mg/kg; i.p.)-induced seizure tests in RACK1 fl/fl or RACK1 cKO mice.

  • 1/16

    Pilocarpine purchased from MedChemExpress. Usage Cited in: Immunity. 2022 Aug 9;55(8):1466-1482.e9. [Abstract]

    Customer Validation
     The effects of tamoxifen treatment and microglial PDGFB ablation on pilocarpine (100 mg/kg, ip, once every 20 minutes)-induced epilepsy were investigated by implanting telemetry probes into PDGFBNull-MG mice and analyzing their heart rate (HR) and heart rate variability (HRV) before and 3 or 5 weeks after tamoxifen treatment.

  • 1/16

    Pilocarpine purchased from MedChemExpress. Usage Cited in: Cell Mol Neurobiol. 2022 Apr;42(3):777-790. [Abstract]

    Customer Validation
     Pilocarpine (325 mg/kg, ip, single dose)-induced status epilepticus (SE) reduced the level of ALOXE3 protein in the hippocampus of mice, but did not reduce it in the temporal lobe cortex.

  • 1/16

    Pilocarpine purchased from MedChemExpress. Usage Cited in: Cell Mol Neurobiol. 2022 Apr;42(3):777-790. [Abstract]

    Customer Validation
     Pilocarpine (325 mg/kg, ip, single dose)-induced status epilepticus (SE) increases AA levels in the hippocampus of mice.

  • 1/16

    Pilocarpine purchased from MedChemExpress. Usage Cited in: Prog Neurobiol. 2022 Oct:217:102335. [Abstract]

    Customer Validation
     The percentages of Foxp3+ Tregs among CD4+ T cells significantly increased in the hippocampal parenchyma of Pilocarpine(280-300 mg/kg; i.p.)-induced SE mice compared with those in the control group.

  • 1/16

    Pilocarpine purchased from MedChemExpress. Usage Cited in: Prog Neurobiol. 2022 Oct:217:102335. [Abstract]

    Customer Validation
     GFAP immunostaining in the CA1, CA3, and DG regions of the hippocampi of vehicle-treated control mice, PC61-treated control mice, vehicle-treated Pilocarpine (280-300 mg/kg; i.p.) mice, and PC61-treated Pilocarpine mice.

  • Pilocarpine