CD28
CD28 is the prototypical co-stimulatory receptor of the Ig superfamily and the principal engine of productive T-cell activation. CD28 is a disulfide-linked homodimeric glycoprotein expressed on most naive human T cells and a subset of memory and regulatory T cells, binding B7-1 (CD80) and B7-2 (CD86) on antigen-presenting cells via its MYPPPY motif. Ligation concurrent with TCR signaling activates LCK-dependent tyrosine phosphorylation of its YMNM motif, recruiting PI3K, GRB2/GADS and ITK, which amplifies Akt-mTOR signaling, calcium flux, NF-κB and AP-1 activity, metabolic reprogramming toward glycolysis and IL-2 production, and prevents anergy while promoting survival, proliferation and differentiation. CD28 also licenses Treg homeostasis and thymic selection. Because tumor-infiltrating lymphocytes require CD28 for PD-1 blockade efficacy, superagonistic CD28 activation (TGN1412 trial) and its dangerous cytokine release syndrome reshaped drug-development safety testing; CD28 co-stimulation remains central to CAR design and vaccine strategies.
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CD28 Recombinant Proteins (17)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 1
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
