Salviandulin E
Salviandulin E is a diterpenoid compound that can be isolated from Salvia leucantha CAV.. Salviandulin E shows antitrypanosomal activity against T. b. brucei GUTat 3.1 parasites with an IC50 value of 0.72 µg/mL.
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- CAS. Nr.: 158994-32-2
- Formel: C20H16O6
- Molecular Weight:352.34
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
Beschreibung
IC50 & Target
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Trypanosoma |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| MRC5 | IC50 |
0.84 μg/mL
Compound: 1
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Cytotoxicity against human MRC5 cells
Cytotoxicity against human MRC5 cells
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[PMID: 24388808] |
In Vitro
Salviandulin E shows cytotoxicity in MRC-5 cells with an IC50 value of 0.84 µg/mL[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS. Nr. 158994-32-2
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Molecular Weight 352.34
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Formel C20H16O6
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SMILES
CC1=C2[C@@]3(C=CC4=C1[C@H](C5=COC=C5)OC4=O)C(C(OC3)=O)=C[C@@H](C2)O
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Reinheit & Dokumentation
Verweise
[1]. Narukawa Y, et al. A novel diterpenoid with a rearranged neoclerodane skeleton from Salvia leucantha CAV. J Nat Med. 2006 Jul;60(3):206-209. [Content Brief]
[2]. Aoyagi Y, et al. Semisynthesis of salviandulin E analogues and their antitrypanosomal activity. Bioorg Med Chem Lett. 2014 Jan 15;24(2):442-6. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Salviandulin E Related Classifications
HY-N11550 Related Classifications
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