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Art. -Nr.: HY-N19136

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SB87-Cl

SB87-Cl is a halogenated benzophenone antibiotic that can be isolated from fungi of the genus Pestalotiopsis. SB87-Cl exhibits strong antibacterial activity against Gram-positive bacteria, but is accompanied by cytotoxicity to mammalian cells. SB87-Cl can be used in studies of Staphylococcus aureus infection, methicillin (Methicillin (HY-121544))-resistant Staphylococcus aureus (MRSA) infection, and vancomycin (Vancomycin (HY-B0671))-susceptible Enterococcus faecium (VSE) infection.

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CAS. Nr.: 163768-83-0
Formel: C₂₀H₁₈Cl₂O₆
Molecular Weight:425.26

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

SB87-Cl Chemical Structure

CAS. Nr.: 163768-83-0

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Biologische Aktivität
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- In Vitro
Chemical Information
Reinheit & Dokumentation
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Calculators
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Biologische Aktivität

Beschreibung

Alle Antibiotic Isoform-spezifische Produkte anzeigen :

In Vitro

SB87-Cl (0.31-10 μg/mL; 6-8 h) exhibits antibacterial activity against Staphylococcus aureus (MIC = 2.5 μg/mL), methicillin-resistant Staphylococcus aureus (MIC = 2.5 μg/mL), and vancomycin-sensitive Enterococcus faecium (MIC = 1.25 μg/mL), but shows no inhibitory effect on vancomycin-resistant Enterococcus faecium even at concentrations up to 10 μg/mL^[1].
SB87-Cl (0.016-50 μM) exhibits cytotoxicity against A549, HeLa, HepG2, MCF-7 and Vero cells, with IC₅₀ values of 2.9, 2.1, 3.9, 4.6 and 2.4 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 163768-83-0
Molecular Weight 425.26
Formel C₂₀H₁₈Cl₂O₆
SMILES

O=CC1=C(C=C(C(C/C=C(C)\C)=C1C(C2=C(C(Cl)=C(C)C(Cl)=C2O)O)=O)O)O
Structure Classification
- Phenols
- Polyphenols
Initial Source
- Microorganisms
Chrysosporium
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Jiang Z, et al. Pestalotinones A-D, new benzophenone antibiotics from endophytic fungus Pestalotiopsis trachicarpicola SC-J551. The Journal of antibiotics. 2022 Apr;75(4):207-212. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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SB87-Cl

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