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Art. -Nr.: HY-164956

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TB-9

TB-9, a Tasiamide B (HY-N15154) derivative, is a potent cathepsin D, cathepsin E, and BACE1 inhibitor with IC₅₀s of 0.0783 nM, 0.724 nM, and 54.2 nM, respectively.

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CAS. Nr.: 1415033-91-8
Formel: C₅₅H₇₆N₈O₁₂
Molecular Weight:1041.24

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

TB-9 Chemical Structure

CAS. Nr.: 1415033-91-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

TB-9, a Tasiamide B (HY-N15154) derivative, is a potent cathepsin D, cathepsin E, and BACE1 inhibitor with IC₅₀s of 0.0783 nM, 0.724 nM, and 54.2 nM, respectively^[1].

IC₅₀ & Target^[1]

Cathepsin D

0.0783 nM (IC₅₀)

Cathepsin E

0.724 nM (IC₅₀)

BACE1

54.2 nM (IC₅₀)

Alle Cathepsin Isoform-spezifische Produkte anzeigen :

Alle Beta-secretase Isoform-spezifische Produkte anzeigen :

BACE1
BACE2

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>10 μM Compound: TB-9	Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by CCK-8 assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by CCK-8 assay	[PMID: 35121401]
HepG2	IC₅₀	>10 μM Compound: TB-9	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by CCK-8 assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by CCK-8 assay	[PMID: 35121401]
MDA-MB-231	IC₅₀	>10 μM Compound: TB-9	Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by CCK-8 assay Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by CCK-8 assay	[PMID: 35121401]

Chemical Information

CAS. Nr. 1415033-91-8
Molecular Weight 1041.24
Formel C₅₅H₇₆N₈O₁₂
SMILES

O=C(OCC1=CC=CC=C1)N[C@@H](C(C)C)C(N(C)[C@@H](CCC(N)=O)C(N[C@@H](CC2=CC=CC=C2)[C@@H](O)CC(N[C@@H](CC(C)C)C(N[C@@H](C)C(N(C)[C@H](CC3=CC=CC=C3)C(N4[C@@H](CCC4)C(OC)=O)=O)=O)=O)=O)=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Zhi Li, et al. Design, synthesis, and bioactivities of tasiamide B derivatives as cathepsin D inhibitors. J Pept Sci. 2019 Apr;25(4):e3154. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
Chemical Information
Reinheit & Dokumentation
Verweise

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TB-9

Alle Cathepsin Isoform-spezifische Produkte anzeigen

Alle Beta-secretase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

TB-9 Related Classifications

HY-164956 Related Classifications