2-5A
2-5A is a RNase L activator, signal mediator and innate immune second messenger. 2-5A induces the expression of interferons and interferon-stimulated genes in recipient cells in a RNase L-dependent manner. 2-5A inhibits tumor growth in mouse models via paracrine RNase L activation derived from cancer cells. 2-5A can be used in studies related to viral infection and cancer.
For research use only. We do not sell to patients.
- CAS No.: 65954-93-0
- Formula: C30H40N15O25P5
- Molecular Weight:1165.59
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
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RNASE L |
2-5A induces paracrine RNase L activation in co-cultured A549 human lung adenocarcinoma epithelial cell lines, with activation triggered by poly(I:C) treatment or expression of the constitutively active OAS1A76V mutant[1].
2-5A is exported extracellularly by poly(I:C)-stimulated MC38 murine colon adenocarcinoma cells via the ABCC10 and ABCC1 transporters[1].
Trimeric 2-5A is taken up by HEK293T human embryonic kidney cells and BJ1 human foreskin fibroblasts to induce RNase L-dependent IFN/ISG activation, with LRRC8A and P2X7R contributing to 2-5A import in HEK293T cells[1].
2-5A export via gap junctions (A549 cells) or ABCC10 (MC38 cells) mediates paracrine OAS-RNase L activation and antiviral immunity against VSV and SeV infection[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 65954-93-0
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Molecular Weight 1165.59
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Formula C30H40N15O25P5
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SMILES
NC1=NC=NC2=C1N=CN2[C@H]3[C@H](OP(O)(OC[C@@H](O[C@H]([C@@H]4OP(O)(OC[C@@H](O[C@H]([C@@H]5O)N6C=NC7=C6N=CN=C7N)[C@H]5O)=O)N8C=NC9=C8N=CN=C9N)[C@H]4O)=O)[C@H](O)[C@@H](COP(OP(OP(O)(O)=O)(O)=O)(O)=O)O3
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Synonyms
2′,5′-ApApA; 2′,5′-trioligoadenylate; 5'-O-Triphosphoryladenylyl-(2'→5')-adenylyl-(2'→5')-adenosine
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
2-5A Related Classifications
HY-173189 Related Classifications
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