Milbemycin A4
Based on 1 Customer Validation
Milbemycin A4 inhibits P-glycoprotein activity, and reverses multidrug resistance of tumor cells. Milbemycins are a family of macrolide antibiotics with insecticidal and acaricidal activity.
For research use only. We do not sell to patients.
- Purity: 99.13%
- CAS No.: 51596-11-3
- Formula: C32H46O7
- Molecular Weight:542.70
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Antibiotic Isoforms
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Biological Activity
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Macrolide |
Chemical Information
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CAS No. 51596-11-3
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Appearance Solid
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Molecular Weight 542.70
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Formula C32H46O7
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Color White to off-white
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SMILES
O=C1[C@]2([H])C=C(C)[C@@H](O)[C@]3([H])[C@@]2(O)/C(CO3)=C/C=C/[C@H](C)C/C(C)=C/C[C@]4([H])C[C@@](O1)([H])C[C@@]5(O[C@H](CC)[C@@H](C)CC5)O4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL (184.26 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (277 KB)
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SDS (787 KB)
- English - EN (787 KB)
- Français - FR (787 KB)
- Deutsch - DE (787 KB)
- Norwegian - NO (787 KB)
- Español - ES (787 KB)
- Swedish - SV (787 KB)
- Italian - IT (787 KB)
- Korean - KR (787 KB)
- Portuguese - PT (787 KB)
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Handling Instructions (2659 KB)
References
[1]. Li J, et al. Isolation and identification of new macrocyclic lactones from a genetically engineered strain Streptomyces bingchenggensis BCJ60. J Antibiot (Tokyo). 2017 Mar;70(3):297-300. [Content Brief]
[2]. Takiguchi Y, et al. Milbemycins, a new family of macrolide antibiotics: fermentation, isolation and physico-chemical properties. J Antibiot (Tokyo). 1980 Oct;33(10):1120-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8426 mL | 9.2132 mL | 18.4264 mL | 46.0660 mL |
| 5 mM | 0.3685 mL | 1.8426 mL | 3.6853 mL | 9.2132 mL | |
| 10 mM | 0.1843 mL | 0.9213 mL | 1.8426 mL | 4.6066 mL | |
| 15 mM | 0.1228 mL | 0.6142 mL | 1.2284 mL | 3.0711 mL | |
| 20 mM | 0.0921 mL | 0.4607 mL | 0.9213 mL | 2.3033 mL | |
| 25 mM | 0.0737 mL | 0.3685 mL | 0.7371 mL | 1.8426 mL | |
| 30 mM | 0.0614 mL | 0.3071 mL | 0.6142 mL | 1.5355 mL | |
| 40 mM | 0.0461 mL | 0.2303 mL | 0.4607 mL | 1.1516 mL | |
| 50 mM | 0.0369 mL | 0.1843 mL | 0.3685 mL | 0.9213 mL | |
| 60 mM | 0.0307 mL | 0.1536 mL | 0.3071 mL | 0.7678 mL | |
| 80 mM | 0.0230 mL | 0.1152 mL | 0.2303 mL | 0.5758 mL | |
| 100 mM | 0.0184 mL | 0.0921 mL | 0.1843 mL | 0.4607 mL |
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