Poly(C)
Poly(C) (Polycytidylic acid) is a pleiotropic immunostimulant that specifically binds to TLR3, RIG-I and MDA5 receptors. Poly (C) recruits adaptor proteins to activate downstream signaling pathways and induce the production of type I interferons and inflammatory cytokines. Poly (C) triggers cancer cell apoptosis via the intrinsic or extrinsic caspase pathway, thereby exerting inhibitory effects on tumor growth and metastasis. Poly (C) acts as a vaccine adjuvant to modify the tumor microenvironment, regulate the expression of endothelial adhesion molecules and induce virus-like immune responses. Poly (C) can be applied to research related to melanoma, various solid tumors, hematological malignancies and autoimmune insulin-dependent diabetes mellitus.
For research use only. We do not sell to patients.
- CAS No.: 30811-80-4
- Formula: (C9H14N3O8P)x
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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TLR3 |
Poly (C) (0.15 M NaCl) forms a 1:1 complex with high-molecular-weight polyguanylic acid, and the apparent cooperative dissociation pK of this complex in 0.15 M NaCl is 12.27, indicating that its stability is higher than that of poly G alone[2].
Poly (C) forms a stable complex with alkali-degraded polyguanylic acid at a nucleotide ratio of 2:1 in a system containing 0.1 M Na+Cl−, 0.05 M sodium cacodylate, pH 7.0[2].
Poly (C) undergoes reversible thermal denaturation in a 50% methanol solution containing 0.1 M NaCl and 0.01 M sodium cacodylate at pH 7.0, and dissociates in an 80% methanol solution at 20°C[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 30811-80-4
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Formula (C9H14N3O8P)x
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SMILES
NC(C=CN1[C@H]2[C@H](O)[C@H](O)[C@@H](COP(O)(O)=O)O2)=NC1=O.[n]
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Synonyms
Polycytidylic acid
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Poly(C) Related Classifications
HY-W682115 Related Classifications
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