1. Apoptosis
  2. Bcl-2 Family
  3. Bax activator-1

Bax activator-1 

Cat. No.: HY-122760
Handling Instructions

Bax activator-1 (compound 106) is a Bax activator that induces Bax-dependent tumor cell apoptosis.

For research use only. We do not sell to patients.

Bax activator-1 Chemical Structure

Bax activator-1 Chemical Structure

CAS No. : 1638526-94-9

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Bax activator-1 (compound 106) is a Bax activator that induces Bax-dependent tumor cell apoptosis[1].

IC50 & Target[1]



In Vitro

Bax activator-1 (20-80 μM; 48 hours) induces Bax-dependent tumor cell apoptosis in a dose-dependent fashion[1].

Apoptosis Analysis[1]

Cell Line: Lewis Lung Carcinoma tumor cells, human non-small cell lung carcinoma A549 cells, human pancreatic carcinoma Panc-1 cells
Concentration: 20 μM, 40 μM , 60 μM , 80 μM
Incubation Time: 48 hours
Result: Induced apoptotic cell death in the murine Lewis Lung Carcinoma (LLC), human non-small cell lung carcinoma A549 cells and PANC-1 human pancreatic carcinoma cells in a dose-dependent fashion.
In Vivo

Bax activator-1 (40 mg/kg; given i.p., each day for 13 days) inhibits lung tumor growth in C57BL/6 female mice[1].

Animal Model: Eight-week old C57BL/6 female mice (with Lewis Lung Carcinoma tumor cells)[1]
Dosage: 40 mg/kg
Administration: Given i.p., each day for 13 days
Result: Exhibited anti-tumor activity as a single-agent.
Molecular Weight







O=C(C1=NN(CC2=CC=CC(OC)=C2)C3=C1CN(CC4=CC=C(C)C(C)=C4)CC3)N5C[[email protected]](O)CCC5


Room temperature in continental US; may vary elsewhere.


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Bax activator-1Bax activator1Bax activator 1Bcl-2 FamilyApoptosisInhibitorinhibitorinhibit

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