Cat. No.: HY-108567

Bisphenol A diglycidyl ether

Name: Bisphenol A diglycidyl ether
Brand: MedChemExpress
SKU: HY-108567
Price: 25.00 USD
Availability: InStock
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Bisphenol A diglycidyl ether is a synthesis product of Bisphenol A (HY-18260). Bisphenol A diglycidyl ether inhibits CYP19 activity in a dose-dependent manner and weakly induces ROS generation. Bisphenol A diglycidyl ether has antiestrogenic effects on vitellogenin production. Bisphenol A diglycidyl ether disrupts the lipidome by reducing diacylglycerols, triglycerides, and membrane lipids. Bisphenol A diglycidyl ether is widely used in protective coatings for food and beverage cans, as well as in various paints and adhesives.

For research use only. We do not sell to patients.

Purity : 95.0%
CAS No.: 1675-54-3
Formula: C₂₁H₂₄O₄
Molecular Weight:340.42

Storage:

Store at room temperature 3 years.

In solvent -80°C, 2 years , -20°C, 1 year

Bisphenol A diglycidyl ether Chemical Structure

CAS No.: 1675-54-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Cytochrome P450 Isoforms :

All Estrogen Receptor/ERR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
JEG-3	IC50	39 μM	Inhibition of CYP19 (aromatase) activity in human placental choriocarcinoma JEG-3 cells incubated for 24 hrs, measured by the conversion of 1β-3H-androst-4-ene-3,17-dione to 3H2O. Inhibition of CYP19 (aromatase) activity in human placental choriocarcinoma JEG-3 cells incubated for 24 hrs, measured by the conversion of 1β-3H-androst-4-ene-3,17-dione to 3H2O.	30366299
JEG-3	EC50	43 μM	Cytotoxicity against human placental choriocarcinoma JEG-3 cells assessed as reduction in cell viability after 24 hrs exposure by Alamar Blue assay. Cytotoxicity against human placental choriocarcinoma JEG-3 cells assessed as reduction in cell viability after 24 hrs exposure by Alamar Blue assay.	30366299
JEG-3	EC50	38 μM	Cytotoxicity against human placental choriocarcinoma JEG-3 cells assessed as reduction in cell viability after 24 hrs exposure by CFDA-AM assay. Cytotoxicity against human placental choriocarcinoma JEG-3 cells assessed as reduction in cell viability after 24 hrs exposure by CFDA-AM assay.	30366299

In Vitro

Lipid MetabolismOxidative StressOthers

Lipid Metabolism

Bisphenol A diglycidyl ether (20-40 µM; 24 h) alters the lipidome of JEG-3 cells, causing a significant decrease of long chain unsaturated PCs (38:2, 38:3, 40:7) and DGs (34:1, 34:3, 36:2), together with an accumulation of TG 48:2 and 50:2^[3].

Oxidative Stress

Bisphenol A diglycidyl ether (100 μM; 1 h) weakly induces ROS generation in JEG-3 cells at a nominal concentration of 100 μM after 1 h exposure^[3].

Others

Bisphenol A diglycidyl ether (10-200 μM; 24 h) inhibits CYP19 activity in JEG-3 cells in a dose-dependent manner with a nominal IC₅₀ of 39 μM, and this inhibition is mostly attributed to its cytotoxicity^[3].
Bisphenol A diglycidyl ether (5-200 μM; 24 h) exhibits significant cytotoxicity in JEG-3 cells after 24 h exposure with EC₅₀ values of 43 μM (Alamar Blue) and 38 μM (CFDA-AM)^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[3]

Cell Line:

JEG-3
Concentration:

5 to 200 μM
Incubation Time:

24 h
Result:

Showed significant cytotoxicity with EC₅₀ values of 43 μM as measured by Alamar Blue and 38 μM as measured by CFDA-AM.

In Vivo

Bisphenol A diglycidyl ether has anti-estrogenic effects on vitellogenin production in male carp^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

ROS/oxidative-stress fluorescent staining

Chemical Information

CAS No. 1675-54-3
Appearance Viscous Liquid
Molecular Weight 340.42
Formula C₂₁H₂₄O₄
Color Colorless to light yellow
SMILES

CC(C1=CC=C(OCC2OC2)C=C1)(C3=CC=C(OCC4OC4)C=C3)C
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (293.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.9375 mL

14.6877 mL

29.3755 mL

5 mM

0.5875 mL

2.9375 mL

5.8751 mL

10 mM

0.2938 mL

1.4688 mL

2.9375 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

Dilution Calculator

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
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Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (538 KB)
- English - EN (538 KB)
- Français - FR (538 KB)
- Deutsch - DE (538 KB)
- Norwegian - NO (538 KB)
- Español - ES (538 KB)
- Swedish - SV (538 KB)
- Italian - IT (538 KB)
- Korean - KR (538 KB)
- Portuguese - PT (538 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yonekubo J, et al. Concentrations of bisphenol a, bisphenol a diglycidyl ether, and their derivatives in canned foods in Japanese markets. Journal of agricultural and food chemistry. 2008 Mar 26;56(6):2041-7.

[2]. Wang L, et al. Widespread occurrence and accumulation of bisphenol A diglycidyl ether (BADGE), bisphenol F diglycidyl ether (BFDGE) and their derivatives in human blood and adipose fat. Environmental science & technology. 2015 Mar 03;49(5):3150-7. [Content Brief]

[3]. Marqueño A, et al. Toxic effects of bisphenol A diglycidyl ether and derivatives in human placental cells. Environmental pollution (Barking, Essex : 1987). 2019 Jan;244:513-521.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.9375 mL	14.6877 mL	29.3755 mL	73.4387 mL
	5 mM	0.5875 mL	2.9375 mL	5.8751 mL	14.6877 mL
	10 mM	0.2938 mL	1.4688 mL	2.9375 mL	7.3439 mL
	15 mM	0.1958 mL	0.9792 mL	1.9584 mL	4.8959 mL
	20 mM	0.1469 mL	0.7344 mL	1.4688 mL	3.6719 mL
	25 mM	0.1175 mL	0.5875 mL	1.1750 mL	2.9375 mL
	30 mM	0.0979 mL	0.4896 mL	0.9792 mL	2.4480 mL
	40 mM	0.0734 mL	0.3672 mL	0.7344 mL	1.8360 mL
	50 mM	0.0588 mL	0.2938 mL	0.5875 mL	1.4688 mL
	60 mM	0.0490 mL	0.2448 mL	0.4896 mL	1.2240 mL
	80 mM	0.0367 mL	0.1836 mL	0.3672 mL	0.9180 mL
	100 mM	0.0294 mL	0.1469 mL	0.2938 mL	0.7344 mL

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Bisphenol A diglycidyl ether

All Cytochrome P450 Isoforms

All Estrogen Receptor/ERR Isoforms