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Cat. No.: HY-164465

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C086

C086, a novel potent Hsp90 inhibitor, could inhibit cell cycle progression and induce cell apoptosis and anti-metastasis by regulating various mechanisms in different cell types.

For research use only. We do not sell to patients.

CAS No.: 1160107-44-7
Formula: C₂₉H₂₈O₈
Molecular Weight:504.53

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

C086 Chemical Structure

CAS No.: 1160107-44-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

C086, a novel potent Hsp90 inhibitor, could inhibit cell cycle progression and induce cell apoptosis and anti-metastasis by regulating various mechanisms in different cell types^[1].

All HSP Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Colon 26	IC₅₀	8.91 μM Compound: C086	Cytotoxicity against mouse Colon 26 cells after 4 hrs by MTT assay Cytotoxicity against mouse Colon 26 cells after 4 hrs by MTT assay	[PMID: 31336310]
HT-29	IC₅₀	5.42 μM Compound: C086	Cytotoxicity against human HT-29 cells after 4 hrs by MTT assay Cytotoxicity against human HT-29 cells after 4 hrs by MTT assay	[PMID: 31336310]
KM12	IC₅₀	3.9 μM Compound: C086	Cytotoxicity against human KM12 cells after 4 hrs by MTT assay Cytotoxicity against human KM12 cells after 4 hrs by MTT assay	[PMID: 31336310]
SW480	IC₅₀	4.78 μM Compound: C086	Cytotoxicity against human SW480 cells after 4 hrs by MTT assay Cytotoxicity against human SW480 cells after 4 hrs by MTT assay	[PMID: 31336310]
WiDr	IC₅₀	7.32 μM Compound: C086	Cytotoxicity against human WiDr cells after 4 hrs by MTT assay Cytotoxicity against human WiDr cells after 4 hrs by MTT assay	[PMID: 31336310]

In Vitro

C086 combined with Gefitinib damages the molecular chaperone functions of Hsp90 in NSCLC cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1160107-44-7
Molecular Weight 504.53
Formula C₂₉H₂₈O₈
SMILES

O=C(/C=C/C1=CC=C(O)C(OC)=C1)C(CC2=CC(OC)=C(O)C=C2)C(/C=C/C3=CC(OC)=C(O)C=C3)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Liman Wang, et al. Novel Hsp90 Inhibitor C086 Potently Inhibits Non-Small Cell Lung Cancer Cells As A Single Agent Or In Combination With Gefitinib. Cancer Manag Res. 2019 Oct 16:11:8937-8945. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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C086

All HSP Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

C086 Related Classifications

HY-164465 Related Classifications