FOXO3 - forkhead box O3 Gene

Also Known as FOXO2; AF6q21; FKHRL1; FOXO3A; FKHRL1P2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2309

About FOXO3

Cytogenetic location: 6q21 Genomic coordinates (GRCh38): 6:108,559,825-108,684,774 (from NCBI)

This gene has 3 transcripts (splice variants), 176 orthologues, 42 paralogues and is associated with 67 phenotypes. Ubiquitous expression in fat (RPKM 14.1), bone marrow (RPKM 13.9) and 25 other tissues.

Summary

This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for Apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

FOXO3 Products (2)

mRNA	Protein	Name
NM_001455.4	NP_001446.1	forkhead box protein O3
NM_201559.3	NP_963853.1	forkhead box protein O3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	21329882	GOA
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	14734530	GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	20371612	GOA
enables beta-catenin binding	IPI IPI: Inferred from physical interaction	15905404	GOA
enables mitochondrial transcription factor activity	IMP IMP: Inferred from mutant phenotype	29445193	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10102273	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	16751106	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10102273	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to glucose starvation	IDA IDA: Inferred from direct assay	29445193	GOA
involved in mitochondrial transcription	IMP IMP: Inferred from mutant phenotype	29445193	GOA
involved in negative regulation of cell migration	IMP IMP: Inferred from mutant phenotype	19188590	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18393360	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18787191	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	10102273	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	20371612	GOA
acts upstream of or within positive regulation of erythrocyte differentiation	IDA IDA: Inferred from direct assay	14734530	GOA
involved in positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	10102273	GOA
involved in positive regulation of regulatory T cell differentiation	IDA IDA: Inferred from direct assay	30513302	GOA
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	14734530	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10102273	GOA
involved in regulation of translation	IDA IDA: Inferred from direct assay	21329882	GOA
involved in tumor necrosis factor-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	15084260	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of RNA polymerase II transcription repressor complex	IPI IPI: Inferred from physical interaction	18393360	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	10102273	GOA
located in cytosol	IDA IDA: Inferred from direct assay	23640897	GOA
colocalizes with mitochondrial matrix	IDA IDA: Inferred from direct assay	29445193	GOA
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	29445193	GOA
colocalizes with mitochondrion	IDA IDA: Inferred from direct assay	23283301	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10102273	GOA
located in nucleus	IMP IMP: Inferred from mutant phenotype	29445193	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	23283301	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FOXO3 Protein Structure

Forkhead

0
200
400
600
673 a.a.

Protein Preferred Names	Protein Names
forkhead box protein O3	FOXO3A-

FOXO3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FOXO3	O43524	PNKP	Homo sapiens	Q96T60	TAP	25609649
Cross	FOXO3	O43524	Foxg1	Mus musculus	Q60987	Anti Tag CoIP	15084259
Cross	FOXO3	O43524	Foxg1	Mus musculus	Q60987	Pull Down	15084259
Intra	FOXO3	O43524	TAF5L	Homo sapiens	O75529	TAP	25609649
Intra	FOXO3	O43524	SIRT1	Homo sapiens	Q96EB6	Anti Bait CoIP	15126506
Intra	FOXO3	O43524	SIRT1	Homo sapiens	Q96EB6	Anti Bait CoIP	14976264
Intra	FOXO3	O43524	FOXK1	Homo sapiens	P85037	TAP	25609649
Intra	FOXO3	O43524	ARHGEF2	Homo sapiens	Q92974	TAP	25609649
Intra	FOXO3	O43524	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	10102273
Intra	FOXO3	O43524	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	11864996
Intra	FOXO3	O43524	SMAD3	Homo sapiens	P84022	Anti Tag CoIP	15084259
Intra	FOXO3	O43524	SMAD3	Homo sapiens	P84022	Pull Down	15084259
Intra	FOXO3	O43524	SMAD4	Homo sapiens	Q13485	Anti Bait CoIP	21532621
Intra	FOXO3	O43524	SMAD4	Homo sapiens	Q13485	Anti Tag CoIP	15084259
Intra	FOXO3	O43524	SMAD4	Homo sapiens	Q13485	Pull Down	15084259
Cross	FOXO3	O43524	Ywhaz	Mus musculus	P63101	Affinity Techniques	21621563
Intra	FOXO3	O43524	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	20562859
Intra	FOXO3	O43524	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	FOXO3	O43524	HCFC1	Homo sapiens	P51610	Anti Tag CoIP	21909281
Intra	FOXO3	O43524	MYC	Homo sapiens	P01106	Anti Tag CoIP	18393360
Intra	FOXO3	O43524	MYC	Homo sapiens	P01106	Anti Bait CoIP	18393360
Intra	FOXO3	O43524	RB1	Homo sapiens	P06400	TAP	25609649
Intra	FOXO3	O43524	ESR1	Homo sapiens	P03372	Anti Bait CoIP	18312651
Intra	FOXO3	O43524	ESR1	Homo sapiens	P03372	Pull Down	18312651
Intra	FOXO3	O43524	ESR1	Homo sapiens	P03372	SIA	18312651
Intra	FOXO3	O43524	ESR1	Homo sapiens	P03372	Anti Tag CoIP	18312651
Intra	FOXO3	O43524	ESR2	Homo sapiens	Q92731	Anti Tag CoIP	18312651
Intra	FOXO3	O43524	ESR2	Homo sapiens	Q92731	Anti Bait CoIP	18312651
Intra	FOXO3	O43524	ESR2	Homo sapiens	Q92731	Pull Down	18312651
Intra	FOXO3	O43524	CREBBP	Homo sapiens	Q92793	TAP	25609649
Intra	FOXO3	O43524	RBL1	Homo sapiens	P28749	TAP	25609649
Intra	FOXO3	O43524	CDC27	Homo sapiens	P30260	TAP	25609649

Cross: Cross-species interaction Intra: Intraspecies interaction

FOXO3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80461	Phospho-FOXO3A(Ser253) Antibody (YA196)	WB, IHC-P	Human, Mouse, Rat
HY-P80677	FOXO3A Antibody (YA428)	WB	Human
HY-P80677A	FOXO3A Antibody (YA428)(PBS only)	WB	Human
HY-P80817	Phospho-FOXO3A (Ser253) Antibody (YA197)	WB	Human, Mouse, Rat
HY-P80817A	Phospho-FOXO3A (Ser253) Antibody (YA197)(PBS only)	WB	Human, Mouse, Rat
HY-P86548	Phospho-FOXO3A(Ser253) Antibody (YA6240)	WB, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Aging
Rhabdomyosarcoma
Leukemia	Leukemias Leukaemia, Unspecified, Without Mention Of Remission Aleukemic Leukaemia Chronic Leukaemia Subacute Leukaemia Leukaemia Disorder Leukaemia Nos
Myeloid Leukemia	Myeloid Leukaemia Leukaemia Myelogenous Leukemia Myelogenous Myeloid Granulocytic Leukaemia Myeloid Granulocytic Leukemia Non-Lymphocytic Leukemia Leukemia, Myeloid Granulocytic Leukaemia Myelogenous Leukaemia Myeloid Leukaemia, Unspecified, Without Mention Of Remission
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Adenoid Cystic Carcinoma	Adenocystic Carcinoma Cribriform Carcinoma Cylindroma Carcinoma Adenoid Cystic Carcinoma, Adenoid Cystic Adenoid Cystic Carcinoma Of Salivary Gland Eccrine Dermal Cylindroma Carcinoma, Cribriform
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Huntington Disease	Huntington'S Disease Huntington Chorea Huntington'S Chorea HD Huntington Chronic Progressive Hereditary Chorea Juvenile Huntington Disease Chronic Progressive Chorea Chronic Progressive Hereditary Chorea Hc - [Huntington Chorea] Hereditary Chorea Progressive Hereditary Chorea
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Premature Menopause	Primary Ovarian Insufficiency Premature Ovarian Failure Hypergonadotropic Hypogonadism Premature Ovarian Insufficiency Menopause - Premature Menopause Praecox Menopause Premature Menopause, Premature Female Hypergonadotropic Hypogonadism Hypergonadotrophic Ovarian Failure Primary Female Hypogonadism Pof - [Premature Ovarian Failure] Ovarian Failure Ovarian Secretion Suppression Ovary Hyposecretion Ovary Secretion Deficiency Premature Menopause Nos
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Leukemia, Chronic Myeloid	Chronic Myeloid Leukemia Chronic Myelogenous Leukemia CML Chronic Granulocytic Leukemia Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib Chronic Myeloid Leukaemia Chronic Granulocytic Leukaemia Chronic Myelogenous Leukaemia Myeloid Leukemia, Chronic Leukemia, Chronic Myelogenous Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic Cml - Chronic Myelogenous Leukemia Cgl Chronic Myelocytic Leukemia Leukemia, Chronic Myeloid, Atypical ACML Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Myeloid Leukemia Chronic Leukemia, Myeloid, Chronic Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Cml- [Chronic Myeloid Leukaemia] Cgl - [Chronic Granulocytic Leukaemia] Chronic Myelocytic Leukaemia
Neural Tube Defects	Spina Bifida Neural Tube Defect NTD Neural Tube Defects, Susceptibility To Spinal Dysraphism Spina Bifida, Susceptibility To Rachischisis Cleft Spine Open Spine Hydrocele Spinalis Neural Tube Defect Nos Sb - [Spina Bifida] Spinal Hernia Nos Spinal Fissure Nos
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Microphthalmia	Microphthalmos Isolated Anophthalmia-Microphthalmia Syndrome Isolated Microphthalmia-Anophthalmia-Coloboma Simple Microphthalmos Clinical Anophthalmia Isolated Anophthalmia - Microphthalmia Isolated Pure Microphthalmia Mac Spectrum Microphthalmia-Anophthalmia-Coloboma Spectrum Primitive Anophthalmia Globe Of Eye Small Small Eyeball Hypoplasia Of Eye Isolated Nanophthalmos Rudimentary Eye Dysplasia Of Eye
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Intrahepatic Gall Duct Cancer	Malignant Neoplasm Of Intrahepatic Bile Ducts Malignant Neoplasm Of Intrahepatic Gall Duct Ca Intrahepatic Bile Ducts Malignant Neoplasm Of Intrahepatic Biliary Passages Intrahepatic Bile Duct Carcinoma
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Diabetes Mellitus	Diabetes
Cataract	Cataracts Cat - [Cataract] Cataract Form Lens Opacity Lens Opacities
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-154919	DC-Y13-27	Activator	99.52%	Unkown
HY-176902	NSC126188	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	FOXO3	MGD	MGI:1890081
Felis catus	FOXO3	VGNC	VGNC:62344
Bos taurus	FOXO3	VGNC	VGNC:29099
Canis familiaris	FOXO3	VGNC	VGNC:40963
Macaca mulatta	FOXO3	VGNC	VGNC:72704
Rattus norvegicus	FOXO3	RGD	RGD:1309196
Others	FOXO3	NCBI