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Cat. No.: HY-116067

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VU0404251

VU0404251 is a highly potent positive allosteric modulator of mGlu for the study of psychosis.

For research use only. We do not sell to patients.

CAS No.: 1276013-77-4
Formula: C₁₉H₂₃FN₂O₂
Molecular Weight:330.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

VU0404251 Chemical Structure

CAS No.: 1276013-77-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

VU0404251 is a highly potent positive allosteric modulator of mGlu for the study of psychosis^[1].

All mGluR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	7.2 nM Compound: 8v, VU0404251	Positive allosteric modulation of rat mGluR5 expressed in human HEK293 cells assessed as calcium mobilization Positive allosteric modulation of rat mGluR5 expressed in human HEK293 cells assessed as calcium mobilization	[PMID: 22981332]
HEK293	EC₅₀	70 nM Compound: 8v, VU0404251	Positive allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as calcium mobilization Positive allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as calcium mobilization	[PMID: 22981332]

Chemical Information

CAS No. 1276013-77-4
Molecular Weight 330.40
Formula C₁₉H₂₃FN₂O₂
SMILES

O=C(N[C@H](C)C(C)(C)C)C1=CC=C(N=C1)OCC2=CC=CC(F)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Manka JT, et al. Optimization of an ether series of mGlu5 positive allosteric modulators: molecular determinants of MPEP-site interaction crossover. Bioorg Med Chem Lett. 2012 Oct 15;22(20):6481-5. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
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Purity & Documentation
References

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VU0404251

All mGluR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

VU0404251 Related Classifications

HY-116067 Related Classifications