Z52
Based on 1 Customer Validation
Z52 is a Ras protein inhibitor. Z52 can be used for the research of cancer, such as pancreatic cancer.
For research use only. We do not sell to patients.
- Purity: 95.76%
- CAS No.: 3077480-59-9
- Formula: C50H61N9O6S
- Molecular Weight:916.14
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Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 3077480-59-9
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Appearance Solid
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Molecular Weight 916.14
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Formula C50H61N9O6S
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Color Off-white to light yellow
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SMILES
N#CC1(CN)CCN(CC#CC2=C[C@]([C@]3=C(CC(C)(COC([C@H]4NN5CCC4)=O)C)C6=C(C=CC(C7=CSC(C[C@@H](C5=O)NC([C@H]8[C@H]9[C@@H]8COC9)=O)=N7)=C6)N3CC)=C([C@@H](OC)C)N=C2)CC1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 100 mg/mL (109.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (5.46 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0915 mL | 5.4577 mL | 10.9154 mL | 27.2884 mL |
| 5 mM | 0.2183 mL | 1.0915 mL | 2.1831 mL | 5.4577 mL | |
| 10 mM | 0.1092 mL | 0.5458 mL | 1.0915 mL | 2.7288 mL | |
| 15 mM | 0.0728 mL | 0.3638 mL | 0.7277 mL | 1.8192 mL | |
| 20 mM | 0.0546 mL | 0.2729 mL | 0.5458 mL | 1.3644 mL | |
| 25 mM | 0.0437 mL | 0.2183 mL | 0.4366 mL | 1.0915 mL | |
| 30 mM | 0.0364 mL | 0.1819 mL | 0.3638 mL | 0.9096 mL | |
| 40 mM | 0.0273 mL | 0.1364 mL | 0.2729 mL | 0.6822 mL | |
| 50 mM | 0.0218 mL | 0.1092 mL | 0.2183 mL | 0.5458 mL | |
| 60 mM | 0.0182 mL | 0.0910 mL | 0.1819 mL | 0.4548 mL | |
| 80 mM | 0.0136 mL | 0.0682 mL | 0.1364 mL | 0.3411 mL | |
| 100 mM | 0.0109 mL | 0.0546 mL | 0.1092 mL | 0.2729 mL |
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