Delafloxacin
Based on 6 publication(s) in Google Scholar
Delafloxacin (RX-3341; WQ-3034; ABT492) is a broad-spectrum fluoroquinolone antibiotic. Delafloxacin has a broad spectrum of activity that includes drug-resistant Staphylococcus aureus, Streptococcus pneumoniae, and Klebsiella pneumonia.
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- Pureté: 99.90%
- CAS No.: 189279-58-1
- Formule: C18H12ClF3N4O4
- Masse moléculaire:440.76
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
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Publications Citing Use of MedChemExpress (MCE) Delafloxacin
More- Nat Microbiol. 2023 Mar;8(3):410-423. [Abstract]
- Mater Today Commun. 2026 Jun 16;54:115566.
- Antimicrob Agents Chemother. 2022 Dec 20;66(12):e0092122. [Abstract]
- Microbiol Spectr. 2025 Oct 30:e0233825. [Abstract]
- Pathology. 2026 Feb 6:S0031-3025(26)00393-4. [Abstract]
- J Glob Antimicrob Resist. 2025 Aug 8:44:435-441. [Abstract]
Voir tous les produits spécifiques à Isoform Antibiotic
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Activité biologique
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Quinolone |
Delafloxacin (2.5, 10, 40, and 160 mg/kg; subcutaneous injection, 24 h) has moderate terminal elimination half-life (t1/2=0.68 h, 0.79 h, 0.69 h and 1.0 h for 2.5 mg/kg, 10 mg/kg, 40 mg/kg, and 160 mg/kg, respectively)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice with a neutropenic murine lung infection model (four S. aureus , four S. pneumoniae, and four K. pneumoniae strains)[1]
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Dosage:The total daily doses vary from 0.156 to 640 mg/kg/24 h
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Administration:0.03 to 160 mg/kg are administered every 6 h (q6h) to infected mice by subcutaneous injection
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Result:Inhibited S. aureus strains ATCC 29213, ATCC 33591, MW2, R2527 with MICs of 0.008, 0.008, 0.004, and 0.004 mg/L, respectively.
Inhibited S. pneumoniae strains ATCC 10813, ATCC 49619, 145, and 1329 with MICs of 0.03, 0.125, 0.016, and 0.016 mg/L, respectively.
Inhibited K. pneumonia strains ATCC 43816, 4105, 4110, and 81-1260A with MICs of 0.06, 1, 0.5, and 0.06 mg/L, respectively.
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Animal Model:Neutropenic mice[1]
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Dosage:2.5, 10, 40, and 160 mg/kg; 0.2 mL
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Administration:Subcutaneous injection; 24 h
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Result:The maximum drug concentrations (Cmax) concentrations ranged from 2 to 71 mg/L. AUC0-∞ values ranged from 2.8 to 152 mg•h/L and were linear across the 2.5- to 160-mg dosing range. The elimination half-life (t1/2) ranged from 0.7 to 1 h.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 189279-58-1
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Appearance Solid
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Masse moléculaire 440.76
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Formule C18H12ClF3N4O4
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Color Off-white to light yellow
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SMILES
O=C(C1=CN(C2=NC(N)=C(F)C=C2F)C3=C(C=C(F)C(N4CC(O)C4)=C3Cl)C1=O)O
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Synonyms
RX-3341; WQ-3034; ABT492
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (6)
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Journal Impact Factor
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Most Recent
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Nat Microbiol
Characterization of antibiotic resistomes by reprogrammed bacteriophage-enabled functional metagenomics in clinical strains. [Abstract]2023 Mar;8(3):410-423. PMID: 36759752 -
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Antimicrob Agents Chemother
In Vitro and In Vivo Properties of CUO246, a Novel Bacterial DNA Gyrase/Topoisomerase IV Inhibitor. [Abstract]2022 Dec 20;66(12):e0092122. PMID: 36448795 -
Microbiol Spectr
Effect of pH on antimicrobial activity of delafloxacin against Escherichia coli isogenic strains carrying diverse chromosomal and plasmid-mediated fluoroquinolone resistance mechanisms. [Abstract]2025 Oct 30:e0233825. PMID: 41165356 -
Pathology
In vitro activity of recently introduced Gram-positive-specific antimicrobial agents against Australian methicillin-resistant Staphylococcus aureus isolates. [Abstract]2026 Feb 6:S0031-3025(26)00393-4. PMID: 41760492 -
J Glob Antimicrob Resist
Susceptibility of multidrug-resistant Escherichia coli and Klebsiella pneumoniae to oral antibiotics in Australia. [Abstract]2025 Aug 8:44:435-441. PMID: 40784378
Solvant et solubilité
DMSO : 100 mg/mL (226.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (281 KB)
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SDS (396 KB)
- English - EN (396 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.2688 mL | 11.3440 mL | 22.6881 mL | 56.7202 mL |
| 5 mM | 0.4538 mL | 2.2688 mL | 4.5376 mL | 11.3440 mL | |
| 10 mM | 0.2269 mL | 1.1344 mL | 2.2688 mL | 5.6720 mL | |
| 15 mM | 0.1513 mL | 0.7563 mL | 1.5125 mL | 3.7813 mL | |
| 20 mM | 0.1134 mL | 0.5672 mL | 1.1344 mL | 2.8360 mL | |
| 25 mM | 0.0908 mL | 0.4538 mL | 0.9075 mL | 2.2688 mL | |
| 30 mM | 0.0756 mL | 0.3781 mL | 0.7563 mL | 1.8907 mL | |
| 40 mM | 0.0567 mL | 0.2836 mL | 0.5672 mL | 1.4180 mL | |
| 50 mM | 0.0454 mL | 0.2269 mL | 0.4538 mL | 1.1344 mL | |
| 60 mM | 0.0378 mL | 0.1891 mL | 0.3781 mL | 0.9453 mL | |
| 80 mM | 0.0284 mL | 0.1418 mL | 0.2836 mL | 0.7090 mL | |
| 100 mM | 0.0227 mL | 0.1134 mL | 0.2269 mL | 0.5672 mL |
Delafloxacin Related Classifications
HY-14814 Related Classifications
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