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Losartan

(Synonyms: DuP-753)
59 Cited Publications
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Based on 59 publication(s) in Google Scholar

Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.

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  • Pureté: 99.41%
  • CAS No.: 114798-26-4
  • Formule: C22H23ClN6O
  • Masse moléculaire:422.91
  • Stockage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 1 year , -20°C, 6 months
  • Losartan Chemical Structure
    Losartan Chemical Structure
  • Experimental Validation Results for Losartan
  • Experimental Validation Results for Losartan
  • Experimental Validation Results for Losartan
  • Experimental Validation Results for Losartan
  • Experimental Validation Results for Losartan
  • Experimental Validation Results for Losartan
  • Experimental Validation Results for Losartan
  • Experimental Validation Results for Losartan
  • Experimental Validation Results for Losartan
  • Experimental Validation Results for Losartan
  • Experimental Validation Results for Losartan
  • Experimental Validation Results for Losartan
CAS No.: 114798-26-4
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Cell Proliferation/Viability AssayIn Vivo Efficacy StudyApoptosis AnalysisCell Migration/Invasion AssayIHCRT-PCRIFWB
  • In Vivo Efficacy Study
  • Cell Proliferation/Viability Assay
  • In Vivo Efficacy Study
  • Cell Proliferation/Viability Assay
  • Apoptosis Analysis
  • Cell Migration/Invasion Assay
  • RT-PCR
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  • Losartan Chemical Structure
    Losartan Chemical Structure
    1/16
  • 1/16

    Losartan purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Nov 25;16(1):10430. [Abstract]

    Customer Validation
     Blood glucose levels were significantly reduced in EMP-treated mice but remained unchanged with Losartan potassium (LOS, oral, 10 mg/kg/day) treatment.

  • 1/16

    Losartan purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2024 Dec 3:136:156314. [Abstract]

    Customer Validation
     The CCK-8 assay was performed to determine cell viability after Losartan potassium treatment under HG conditions for 48 h.

  • 1/16

    Losartan purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2024 Dec 3:136:156314. [Abstract]

    Customer Validation
     The kidney/body weight ratios demonstrated that both Losartan potassium and PHI exerted nephroprotective effects against DN, with H-PHI treatment exhibiting a greater effect.

  • 1/16

    Losartan purchased from MedChemExpress. Usage Cited in: J Immunother Cancer. 2024 Sep 6;12(9):e009327. [Abstract]

    Customer Validation
     Proliferation ability of MDA-MB-231 and HS578T cells in control and Losartan (10µM)-treated groups was assessed by colony formation assay.

  • 1/16

    Losartan purchased from MedChemExpress. Usage Cited in: J Immunother Cancer. 2024 Sep 6;12(9):e009327. [Abstract]

    Customer Validation
     Apoptosis level of MDA-MB-231 and HS578T cells in control and Losartan (10µM)-treated groups was assessed by flow cytometry assay.

  • 1/16

    Losartan purchased from MedChemExpress. Usage Cited in: J Immunother Cancer. 2024 Sep 6;12(9):e009327. [Abstract]

    Customer Validation
     Migration ability of MDA-MB-231 and HS578T cells in control and Losartan (10µM)-treated groups were assessed by Boyden chamber assay.

  • 1/16

    Losartan purchased from MedChemExpress. Usage Cited in: J Immunother Cancer. 2024 Sep 6;12(9):e009327. [Abstract]

    Customer Validation
     Expression of COL1A1 in control and Losartan (10µM)-treated CAFs was assessed by qPCR and Western blotting assays.

  • 1/16

    Losartan purchased from MedChemExpress. Usage Cited in: J Immunother Cancer. 2024 Sep 6;12(9):e009327. [Abstract]

    Customer Validation
     Expression of COL1A1 in control and Losartan (10µM)-treated CAFs was assessed by immunofluorescence assay.

  • 1/16

    Losartan purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2020 May 22;11(5):390. [Abstract]

    Customer Validation
     Both dapagliflozin and Losartan potassium treatment significantly reduced the urinary albumin levels at 12 weeks.

  • 1/16

    Losartan purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2020 May 22;11(5):390. [Abstract]

    Customer Validation
     Both dapagliflozin and Losartan potassium treatment significantly reduced the NGAL levels at 12 weeks.

  • 1/16

    Losartan purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2020 May 22;11(5):390. [Abstract]

    Customer Validation
     Morphological analysis revealed that glomerular tuft area , mesangial expansion, and mesangial matrix hyperplasia (fractional mesangial area, FMA), which were increased in diabetic mice, were also equally improved by dapagliflozin and Losartan potassium treatment.

  • 1/16

    Losartan purchased from MedChemExpress. Usage Cited in: FASEB J. 2018 Sep;32(9):5051-5062. [Abstract]

    Customer Validation
     HUVECs are starved for 12 h, treated with 10 mg/mL (9.56 μM) of AngII with or without Losartan or PD123319 for 12 h, and are subsequently used for Western blot analysis.

  • Losartan