AA-17010
AA-17010 is a Cereblon ligand with an IC50 of 0.20 μM and a Ki of 0.08 μM. AA-17010 serves as an E3 ligase ligand for the synthesis of PROTAC KRAS degraders, such as CW-10201 (HY-189305).
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- CAS No.: 3064305-88-7
- Formule: C19H22N4O4
- Masse moléculaire:370.40
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
Cereblon 0.20 μM (IC50) |
In Vitro
AA-17010 (~3 h) is a high-affinity Cereblon ligand that binds to CRBN with an IC50 of 0.20 μM and a Ki of 0.08 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 3064305-88-7
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Masse moléculaire 370.40
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Formule C19H22N4O4
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SMILES
O=C(C(N(C(N(C)C1=C2)=O)C1=CC3=C2C4(CCNCC4)CO3)CC5)NC5=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AA-17010 Related Classifications
HY-189348 Related Classifications
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