Anticancer agent 157
Anticancer agent 157 (compound 15) is a NO inhibitor (IC50=0.62 μg/mL) with anti-inflammatory and anticancer activities. Anticancer agent 157 can bind to iNOS (inducible NO synthase) and caspase 8, causing nuclear fragmentation and chromatin condensation, inducing apoptosis. Anticancer agent 157 inhibits HT29 colon cancer cells (IC50=2.45 μg/mL), Hep-G2 liver cancer cells (IC50=3.25 μg/mL), and B16-F10 murine melanoma cells (IC50=3.84 μg/mL).
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- Formule: C14H20O2
- Masse moléculaire:220.31
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
iNOS (inducible nitric-oxide synthase); caspase 8[1]
Chemical Information
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Masse moléculaire 220.31
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Formule C14H20O2
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SMILES
OC1=C(CO)C(C)=C2CCCC(C)(C)C2=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)