AP 24149
AP 24149 is a potent Src-Abl dual inhibitor with IC50 values of 9.1, 3.6 nM for Src and Abl, respectively.
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- CAS No.: 926922-29-4
- Formule: C23H24N5OP
- Masse moléculaire:417.44
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
Abl 3.6 nM (IC50) |
Src 9.1 nM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BaF3 | IC50 |
168 nM
Compound: 10a
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Cytotoxicity against mouse BA/F3 cells transfected with wild-type Bcr-Abl
Cytotoxicity against mouse BA/F3 cells transfected with wild-type Bcr-Abl
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[PMID: 18691885] |
| K562 | IC50 |
109 nM
Compound: 10a
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Cytotoxicity against human K562 cells transfected with wild-type Bcr-Abl
Cytotoxicity against human K562 cells transfected with wild-type Bcr-Abl
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[PMID: 18691885] |
Chemical Information
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CAS No. 926922-29-4
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Masse moléculaire 417.44
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Formule C23H24N5OP
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SMILES
O=P(C)(C)C(C=C1)=CC=C1NC2=C3N=CN(/C=C/C4=C(C)C=CC=C4C)C3=NC=N2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AP 24149 Related Classifications
HY-10363 Related Classifications
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