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Cat. No.: HY-178777

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BCL6-760

BCL6-760 is an orally active BCL-6 PROTAC degrader with an EC₅₀ of 0.8 nM. BCL6-760 only degrades BCL6 and has no effect on other CRBN substrates. BCL6-760 demonstrates significant efficacy in the orthotopic xenograft mouse model of OCI-LY-1 tumors. BCL6-760 can be used in the research of diffuse Large B-cell Lymphoma (DLBCL) (Pink: BCL-6 ligand (HY-179317); Blue: CRBN ligand (HY-179305); Black: Linker).
(Pink: BCL6 ligand (HY-179317); Blue: no E3 ligase ligand; Black: linker).

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 3084696-50-1
Formule: C₃₆H₄₃ClN₁₀O₄
Masse moléculaire:715.24

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

BCL6-760 Chemical Structure

CAS No.: 3084696-50-1

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Activité biologique
- Description
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
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Activité biologique

Description

BCL6-760 is an orally active BCL-6 PROTAC degrader with an EC₅₀ of 0.8 nM. BCL6-760 only degrades BCL6 and has no effect on other CRBN substrates. BCL6-760 demonstrates significant efficacy in the orthotopic xenograft mouse model of OCI-LY-1 tumors. BCL6-760 can be used in the research of diffuse Large B-cell Lymphoma (DLBCL) (Pink: BCL-6 ligand (HY-179317); Blue: CRBN ligand (HY-179305); Black: Linker)^[1]. (Pink: BCL6 ligand (HY-179317); Blue: no E3 ligase ligand; Black: linker).

Voir tous les produits spécifiques à Isoform PROTACs :

In Vitro

BCL6-760 inhibits OCI-LY-1 cells growth with a GI₅₀ of 1.3 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	C_max	T_max	AUC_0-24	F	CL	V_ss	MRT
Mice^[1]	10 mg/kg	p.o.	4.86 μM	1.3 h	15.8 μM·h	22 %	/	/	/
Mice^[1]	2 mg/kg	i.v.	/	/	14.7 μM·h	/	3.53 mL/min/kg	0.25 L/kg	1.2 h

In Vivo

BCL6-760 (15-60 mg/kg, p.o., once or twice daily for 5 days) effectively and continuously degrades the BCL6 protein in tumors, and produces significant anti-tumor effects in OCI-LY-1 tumor xenograft mouse model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3084696-50-1
Masse moléculaire 715.24
Formule C₃₆H₄₃ClN₁₀O₄
SMILES

CN(C1=NC(NC2=CC=C3N(C(N(C3=C2)CCC(C)(O)C)=O)C)=C(C=N1)Cl)C4CCN(C5=CC6=C(C(C7CCC(NC7=O)=O)=NN6C)C=C5)CC4
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Shunatona HP, et al. Discovery of Potent and Selective BCL6 Ligand-Directed Degrader (LDD), BCL6-760. J Med Chem. 2025 Oct 23;68(20):21502-21519. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
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BCL6-760

Voir tous les produits spécifiques à Isoform PROTACs

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

BCL6-760 Related Classifications

HY-178777 Related Classifications