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BIBO3304 diTFA

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Based on 4 publication(s) in Google Scholar

BIBO3304 (diTFA) is an orally effective and selective neuropeptide Y (NPY) Y1 receptor antagonist. BIBO3304 (diTFA) has a high affinity for both human and rat Y1 receptors, with IC50 values of 0.38 and 0.72 nM, respectively. BIBO3304 (diTFA) promotes bone-tendon healing through the Wnt/β-catenin signaling pathway.

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  • CAS No.: 2310085-85-7
  • Formule: C33H37F6N7O7
  • Masse moléculaire:757.68
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  • BIBO3304 diTFA Chemical Structure
    BIBO3304 diTFA Chemical Structure
  • Experimental Validation Results for BIBO3304 diTFA
  • Experimental Validation Results for BIBO3304 diTFA
  • Experimental Validation Results for BIBO3304 diTFA
CAS No.: 2310085-85-7
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  • BIBO3304 diTFA Chemical Structure
    BIBO3304 diTFA Chemical Structure
    1/16
  • 1/16

    BIBO3304 diTFA purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Aug 1;16(1):7074. [Abstract]

    Customer Validation
     Intrathecal injection of NPY1R selective antagonist BIBO3304 (BIBO, 10 μg, 20 min before) blocked the effects of LP-NPY (3 μg) on morphine-induced itch, one-way ANOVA, Dunnett’s multiple comparisons.

  • 1/16

    BIBO3304 diTFA purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Aug 1;16(1):7074. [Abstract]

    Customer Validation
     NPY (10 μM) induced outward currents were recorded and inhibited by BIBO3304(2 μM) from GRP+ interneurons in the SDH from GrpCre;Ai9 mice.

  • 1/16

    BIBO3304 diTFA purchased from MedChemExpress. Usage Cited in: In Vivo. 2024 May-Jun;38(3):1133-1142. [Abstract]

    Customer Validation
     Hypothalamic NPY exerted an antinociceptive effect by binding to Y1R and Y2R in cancer-bearing rats. PWT was measured using von Frey filaments (BIBO3304: 3 μg).

  • BIBO3304 diTFA