Bicyclomycin
Bicyclomycin is an antibiotic. Bicyclomycin exhibits selective antibacterial activity against Gram-negative bacteria such as Escherichia coli and Klebsiella spp., with no cross-resistance. Bicyclomycin is applicable to the research of infectious diseases.
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- CAS No.: 38129-37-2
- Formule: C12H18N2O7
- Masse moléculaire:302.28
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Bicyclomycin (6-25 μg/mL; 2 h) induces dose-dependent morphological changes (cell elongation, spheroplast formation) in actively growing cells of E. coli strain 15 THU and the highly sensitive E. coli strain ATCC 27166[1].
Bicyclomycin (25-100 μg/mL; 0-60 min) inhibits RNA and protein synthesis in proliferating E. coli 15 THU cells, but does not affect their DNA or lipid synthesis[1].
Bicyclomycin (100 μg/mL, over 0-45 min) exerts a stronger inhibitory effect on bound lipoprotein synthesis (inhibition rate of approximately 95%) than on free lipoprotein (inhibition rate of approximately 60%) and envelope protein synthesis (inhibition rate of approximately 50%) in histidine-starved E. coli 15 THU cells, with no effect on cytoplasmic protein synthesis[1].
Bicyclomycin exhibits selective moderate antibacterial activity against specific Gram-negative bacteria (Escherichia coli NIHJ JC-2, Klebsiella pneumoniae ST-101, Salmonella typhosa T-287, Shigella flexneri 1a-2 W-A), with an MIC of 25 mcg/mL; it shows only weak activity against Sarcina lutea PCI-100 (MIC 250 mcg/mL); and it has no activity against other tested Gram-positive bacteria, Gram-negative bacteria, mycobacteria, fungi, or yeasts[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 38129-37-2
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Appearance Solid
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Masse moléculaire 302.28
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Formule C12H18N2O7
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Color White to off-white
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SMILES
OC[C@](C)(O)[C@@H]([C@]12C(N[C@](C(N1)=O)(C(CCO2)=C)O)=O)O
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Structure Classification
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Initial Source
sterptomyces cinnamoneus
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Pureté et documentation
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Fiche technique (278 KB)
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SDS (479 KB)
- English - EN (479 KB)
- Français - FR (479 KB)
- Deutsch - DE (479 KB)
- Norwegian - NO (479 KB)
- Español - ES (479 KB)
- Swedish - SV (479 KB)
- Italian - IT (479 KB)
- Korean - KR (479 KB)
- Portuguese - PT (479 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Bicyclomycin Related Classifications
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