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Cat. No.: HY-120604

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BVB808

Name: BVB808
Brand: MedChemExpress
SKU: HY-120604
Availability: PreOrder

(Synonyms: NVP_BVB808)

BVB808 (NVP_BVB808) is a selective JAK2 inhibitor with approximately 10-fold selectivity for JAK2 over other JAK family members (such as JAK1, JAK3 or TYK2) in vitro. BVB808 inhibits the activity of JAK2 and reduces the phosphorylation of STAT5, thereby blocking the JAK2-dependent cell proliferation and survival signaling pathways. BVB808 can be used in cancer research.

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CAS No.: 1414587-22-6
Formule: C₂₉H₃₃F₂N₇O
Masse moléculaire:533.62

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

BVB808 Chemical Structure

CAS No.: 1414587-22-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

Description

Voir tous les produits spécifiques à Isoform JAK :

Voir tous les produits spécifiques à Isoform STAT :

Chemical Information

CAS No. 1414587-22-6
Masse moléculaire 533.62
Formule C₂₉H₃₃F₂N₇O
SMILES

FC(C=C1N2C3=NC(NC4=CC=C(N5C[C@@H](N[C@@H](C5)C)C)C=C4)=NC=C3C=C2)=C(C(F)=C1)CN6CCOCC6
Synonyms

NVP_BVB808
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Weigert, et al. "Genetic resistance to JAK2 enzymatic inhibitors is overcome by HSP90 inhibition." The Journal of experimental medicine 209.2 (2012): 259. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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BVB808

Voir tous les produits spécifiques à Isoform JAK

Voir tous les produits spécifiques à Isoform STAT

Activité biologique

Description

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

BVB808 Related Classifications

HY-120604 Related Classifications

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