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Cat. No.: HY-185339

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CDK9-IN-48

CDK9-IN-48 is a CDK9 inhibitor with an IC₅₀ of 1.37 nM. CDK9-IN-48 inhibits the proliferation of various cancer cells. CDK9-IN-48 can be used in the research of cancers such as acute myeloid leukemia and prostate cancer.

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CAS No.: 2987897-20-9
Formule: C₂₃H₂₄FN₅O₃S
Masse moléculaire:469.53

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CDK9-IN-48 Chemical Structure

CAS No.: 2987897-20-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]

CDK9

1.37 nM (IC₅₀)

Voir tous les produits spécifiques à Isoform CDK :

In Vitro

CDK9-IN-48 (Example 18) (0.00000256-1 μM, 3 days) potently inhibits the proliferation of MOLM-13 acute myeloid leukemia cells, LNCaP prostate cancer cells, and MV-4-11 acute myeloid leukemia cells, with IC₅₀ values of 0.645, 2.34, and 2.24 nM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

MOLM-13, LNCaP, MV-4-11 cell
Concentration:

0.00000256-1μM, starting with 1 μM, a 5-fold serial dilution was performed to obtain 9 concentrations
Incubation Time:

2 days (post-compound addition, 37°C, 5% CO₂)
Result:

Potently inhibited MOLM-13 cell proliferation with an IC₅₀ of 0.645 nM.
Inhibited LNCaP cell proliferation with an IC₅₀ of 2.34 nM.
Inhibited MV-4-11 cell proliferation with an IC₅₀ of 2.24 nM.

Parmacokinetics

Species	Dose	Route	C_max	T_max	T_1/2	AUC_0-last	CL
Rat^[1]	1 mg/kg	i.v.	1281 ng/mL	0.27 h	2.35 h	1302 ng·h/mL	0.74 L/h/kg
Rat^[1]	1 mg/kg	i.v.	2915 ng/mL	0.08 h	0.99 h	1269 ng·h/mL	0.78 L/h/kg

Chemical Information

CAS No. 2987897-20-9
Masse moléculaire 469.53
Formule C₂₃H₂₄FN₅O₃S
SMILES

CN1C(C(C)(O)C)=C2C=C(C3=C(F)C=NC(NC4=CC(CS(C)(=O)=O)=CC=N4)=C3)C=CC2=N1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Song Liqiang, et al. Aminopyridine derivative, and preparation method therefor and use thereof. WO2023179597A1. 2024-09-25.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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CDK9-IN-48

Voir tous les produits spécifiques à Isoform CDK

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

CDK9-IN-48 Related Classifications

HY-185339 Related Classifications