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Cat. No.: HY-125230

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CN427

CN427 is a quinazoline-based BRD4 inhibitor with a K_d of 66 nM for BRD4. CN427 is applicable to the research of leukemia.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 2260887-54-3
Formule: C₂₈H₂₈N₆O₃
Masse moléculaire:496.57

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CN427 Chemical Structure

CAS No.: 2260887-54-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- Parmacokinetics
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
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Bioz

Activité biologique

Description

CN427 is a quinazoline-based BRD4 inhibitor with a K_d of 66 nM for BRD4. CN427 is applicable to the research of leukemia^[1].

IC₅₀ & Target^[1]

BRD4

66 nM (Kd)

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Cellular Effect

Cell Line	Type	Value	Description	References
MV4-11	IC₅₀	1.1 μM Compound: 65; CN427	Cytotoxicity against human MV411 cells after 72 hrs by CellTiter-Glo assay Cytotoxicity against human MV411 cells after 72 hrs by CellTiter-Glo assay	[PMID: 30268702]
MV4-11	IC₅₀	1.1 μM Compound: 8	Cytotoxicity against human MV4-11 cells assessed as inhibition of cell viability Cytotoxicity against human MV4-11 cells assessed as inhibition of cell viability	[PMID: 30905542]

In Vitro

CN427 inhibits MV4-11 cell viability with an IC₅₀ of 1.10 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	T_1/2	C_max	AUC_0-∞	Bioavailability	V_ss	CL_plasma
Mice^[1]	2 mg/kg	i.v.	3.1 h	1690 ng/mL	1757 ng·h/mL	/	1.7 L/kg	19.8 mL/min/kg
Mice^[1]	10 mg/kg	p.o.	2.1 h	934 ng/mL	4494 ng·h/mL	51 %	/	/

Chemical Information

CAS No. 2260887-54-3
Masse moléculaire 496.57
Formule C₂₈H₂₈N₆O₃
SMILES

OCCN1N=CC(=C1)C2=NC=3C=CC(=CC3C(=N2)N4CCOCC4C=5C=CC=CC5)C=6C(=NOC6C)C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Yang SM, et al. Discovery and lead identification of quinazoline-based BRD4 inhibitors. Bioorg Med Chem Lett. 2018;28(21):3483-3488. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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CN427

Voir tous les produits spécifiques à Isoform Epigenetic Reader Domain

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

CN427 Related Classifications

HY-125230 Related Classifications