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Cat. No.: HY-W742094

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Cycotiamine

Cycotiamine is an S-acylated thiamine derivative with antiplasmodial activity. Cycotiamine inhibits the proliferation of Plasmodium falciparum and Plasmodium knowlesi. Cycotiamine can be used in malaria-related research.

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CAS No.: 6092-18-8
Formule: C₁₃H₁₆N₄O₃S
Masse moléculaire:308.36

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Please store the product under the recommended conditions in the Certificate of Analysis.

Cycotiamine Chemical Structure

CAS No.: 6092-18-8

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Description

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In Vitro

Cycotiamine (compound 12) exhibits IC₅₀ values of 123 μM, 127 μM, and 176 μM against P. falciparum under extracellular thiamine concentrations of 0 μM, 2.97 μM, and 297 μM, respectively. The IC₅₀ of cycotiamine against P. knowlesi exceeds 1000 μM, showing weaker anti-parasitic activity than other thiamine analogs in the same series. The IC₅₀ of cycotiamine against human fibroblast HFF cells exceeds 1000 μM, with no obvious cytotoxicity^[1].
Cycotiamine (serial dilution; 96 h) inhibits the proliferation of both Plasmodium falciparum strain 3D7-GFP and PfTPK-GFP-overexpressing Plasmodium to the same extent, indicating that its anti-Plasmodium effect is independent of thiamine pyrophosphokinase^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 6092-18-8
Masse moléculaire 308.36
Formule C₁₃H₁₆N₄O₃S
SMILES

O=CN(CC1=CN=C(C)N=C1N)/C(C)=C2SC(OCC/2)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Fathoni I, et al. Identification and characterization of thiamine analogs with antiplasmodial activity. Antimicrob Agents Chemother. 2024;68(12):e0109624. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Cycotiamine

Voir tous les produits spécifiques à Isoform Parasite

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Cycotiamine Related Classifications

HY-W742094 Related Classifications