Eletriptan
Based on 1 publication(s) in Google Scholar
Eletriptan (UK-116044) is a highly selective and orally active serotonin 5-HT1B and 5-HT1D receptor agonist, with pKi values of 8.0 and 8.9, respectively. Eletriptan has inhibitory effects on markers of neurogenic inflammation in rats. Eletriptan can be used for researching migraine.
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- CAS No.: 143322-58-1
- Formule: C22H26N2O2S
- Masse moléculaire:382.52
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Stockage:
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Eletriptan
MoreVoir tous les produits spécifiques à Isoform 5-HT Receptor
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Activité biologique
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5-HT1B Receptor |
5-HT1D Receptor |
5-HT1B Receptor 8.0 (pKi) |
5-HT1D Receptor 8.9 (pKi) |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 143322-58-1
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Masse moléculaire 382.52
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Formule C22H26N2O2S
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SMILES
CN1[C@@H](CC2=CNC3=CC=C(CCS(C4=CC=CC=C4)(=O)=O)C=C32)CCC1
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Synonyms
UK-116044
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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J Headache Pain
Regional distribution of unbound eletriptan and sumatriptan in the CNS and PNS in rats: implications for a potential central action. [Abstract]2024 Oct 30;25(1):187. PMID: 39478486
Pureté et documentation
Références
[1]. McCormack PL, Keating GM. Eletriptan: a review of its use in the acute treatment of migraine. Drugs. 2006;66(8):1129-49. [Content Brief]
[2]. Willems E, et al. Porcine carotid vascular effects of eletriptan (UK-116,044): a new 5-HT1B/1D receptor agonist with anti-migraine activity. Naunyn Schmiedebergs Arch Pharmacol. 1998 Aug;358(2):212-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Eletriptan Related Classifications
HY-A0039 Related Classifications
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