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Cat. No.: HY-181126

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G194-0712

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Based on 1 Customer Validation

G194-0712 is a selective histone deacetylase 5 (HDAC5) activator with an EC₅₀ of 7.96 μM and a K_d of 2.53 μM. G194-0712 restores ACTN4-K417 deacetylation and nuclear import, and increases CSTA expression. G194-0712 accelerates wound closure in chronic wound models, reducing wound area and epithelial gap. G194-0712 can be used for the research of chronic skin wounds, such as diabetic wounds, ischemic wounds, radiation injury wounds.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Pureté: 99.82%
CAS No.: 1029737-28-7
Formule: C₂₀H₂₀ClN₃O
Masse moléculaire:353.85

Stockage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

G194-0712 Chemical Structure

CAS No.: 1029737-28-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Solvant et solubilité
- In Vitro
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]

HDAC5

7.96 μM (EC₅₀)

HDAC5

2.53 μM (Kd)

Voir tous les produits spécifiques à Isoform HDAC :

In Vitro

G194-0712 shows EC₅₀ values of 107.2, 100.4 and 111.5 μM for HDAC4, HDAC7 and HDAC9^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

G194-0712 (25 μM; topical application) accelerates diabetic wound healing in C57BLKS/J-db/db mice, ischemic wound healing and irradiated wound healing in C57BL/6J mice by reinstating ACTN4-K417 deacetylation, nuclear import, and CSTA expression, leading to reduced wound area and epithelial gap in and reduced wound area^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BLKS/J-db/db (male, 8 weeks old, chronic wound model); C57BL/6J mice (male, 8 weeks old)^[1]
Dosage:

25 μM
Administration:

Topical application
Result:

Reinstated ACTN4-K417 deacetylation and nuclear import.
Increased CSTA expression and reduced wound area at PODs 5, 9, 14, and 18.
Decreased epithelial gap.

Chemical Information

CAS No. 1029737-28-7
Appearance Solid
Masse moléculaire 353.85
Formule C₂₀H₂₀ClN₃O
Color White to off-white
SMILES

CC(C1=CC=C(C=C1)N2C=CN=C(C2=O)NCC3=CC=CC=C3Cl)C
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvant et solubilité

In Vitro:

DMSO : 10 mg/mL (28.26 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.8261 mL

14.1303 mL

28.2606 mL

5 mM

0.5652 mL

2.8261 mL

5.6521 mL

10 mM

0.2826 mL

1.4130 mL

2.8261 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (271 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Zhang Y, et al. HDAC5 deacetylates cytosolic ACTN4 during skin reepithelialization and represents a therapeutic target for chronic wound healing. Sci Transl Med. 2025;17(830):eads0594. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.8261 mL	14.1303 mL	28.2606 mL	70.6514 mL
	5 mM	0.5652 mL	2.8261 mL	5.6521 mL	14.1303 mL
	10 mM	0.2826 mL	1.4130 mL	2.8261 mL	7.0651 mL
	15 mM	0.1884 mL	0.9420 mL	1.8840 mL	4.7101 mL
	20 mM	0.1413 mL	0.7065 mL	1.4130 mL	3.5326 mL
	25 mM	0.1130 mL	0.5652 mL	1.1304 mL	2.8261 mL

Keywords

100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Solvant et solubilité
- In Vitro
Pureté et documentation
Références

Nom du produit:
Cat. No.:
Quantité:
MCE Japan Authorized Agent:

Nom du produit:
CAS No.:
Species:
Pureté:
Quantité:

G194-0712

Cell Cycle/DNA Damage Compound Library

Epigenetics Compound Library

Immunology/Inflammation Compound Library

Histone Modification Research Compound Library

Anti-Aging Compound Library

Anti-diabetic Compound Library

Oxygen Sensing Compound Library

Anti-Pancreatic Cancer Compound Library

Highly Selective Activators Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Lactylation Compound Library

Voir tous les produits spécifiques à Isoform HDAC

Activité biologique

Chemical Information

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

G194-0712

Cell Cycle/DNA Damage Compound Library

Epigenetics Compound Library

Immunology/Inflammation Compound Library

Histone Modification Research Compound Library

Anti-Aging Compound Library

Anti-diabetic Compound Library

Oxygen Sensing Compound Library

Anti-Pancreatic Cancer Compound Library

Highly Selective Activators Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Lactylation Compound Library

Voir tous les produits spécifiques à Isoform HDAC

Activité biologique

Chemical Information

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

G194-0712 Related Classifications

HY-181126 Related Classifications